Evidence map›Paper›PMID 39201690›Full record

ArticleInternational journal of molecular sciences2024

ShSPI Inhibits Thrombosis Formation and Ischemic Stroke In Vivo.

Ning Luan, Han Cao, Yunfei Wang, Haihao Zhang, Kangyang Lin, Jingping Hu, Mingqiang Rong, Cunbao Liu

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ning LuanInstitute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China.ORCID 0000-0001-8559-7464
Han CaoInstitute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China.
Yunfei WangInstitute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China.
Haihao ZhangInstitute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China.
Kangyang LinInstitute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China.
Jingping HuInstitute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China.
Mingqiang RongNational and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha 410081, China.
Cunbao LiuInstitute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China.

Funding

Funds for High-Level Scientific and Technological Talents Selection Special Project of Yunnan Province 202205AC160015the Major Science and Technology Special Projects of Yunnan Province 202002AA100009the National Key R&D Program of China 2022YFC2305700the National Natural Science Foundation of China 82104130the Special Biomedicine Projects of Yunnan Province 202102AA310035Yunnan Fundamental Research Projects 202201AU070150Yunnan Fundamental Research Projects 202301AT070362
6 · The paper itself

Abstract

Thrombotic diseases, emerging as a global public health hazard with high mortality and disability rates, pose a significant threat to human health and longevity. Although current antithrombotic therapies are effective in treating these conditions, they often carry a substantial risk of bleeding, highlighting the urgent need for safer therapeutic alternatives. Recent evidence has increasingly pointed to a connection between elastase activity and thrombosis. In the current study, we investigated the antithrombotic effects of ShSPI, an elastase inhibitor peptide derived from the venom of

Indexed as

Ischemic StrokeThrombosisAnimalsCarrageenanDisease Models, AnimalFibrinolytic AgentsMaleMiceMice, Inbred C57BLNitric Oxide Synthase Type IIISuperoxide DismutaseCarrageenanFibrinolytic AgentsNitric Oxide Synthase Type IIISuperoxide Dismutaseelastase inhibitorischemic strokeShSPIthrombosisthrombotic diseases

Identifiers

PMID39201690
PMCPMC11354536

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.