Evidence map›Paper›PMID 39201686›Full record

SynthesisInternational journal of molecular sciences2024

The Association between Telomere Length and Head and Neck Cancer Risk: A Systematic Review and Meta-Analysis.

Dimitrios Andreikos, Efthymios Kyrodimos, Athanassios Kotsinas, Aristeidis Chrysovergis, Georgios X Papacharalampous

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dimitrios AndreikosSchool of Medicine, Democritus University of Thrace, 68100 Alexandroupoli, Greece.ORCID 0000-0002-5148-3837
Efthymios KyrodimosFirst Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, National and Kapodistrian University of Athens, 114 Vas Sofias Avenue, 11527 Athens, Greece.
Athanassios KotsinasLaboratory Histology-Embryology, Faculty of Medicine, National and Kapodistrian University of Athens, 75 Mikras Asias Street, Goudi, 11527 Athens, Greece.ORCID 0000-0003-2397-4118
Aristeidis ChrysovergisENT Department, Athens General Hospital "ELPIS", 7 Dimitsanas Street, 11522 Athens, Greece.ORCID 0000-0002-6708-2210
Georgios X PapacharalampousENT Department, Athens General Hospital "ELPIS", 7 Dimitsanas Street, 11522 Athens, Greece.ORCID 0000-0002-4649-3694

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Telomeres play a crucial role in maintaining chromosomal integrity and regulating the number of cell divisions and have been associated with cellular aging. Telomere length (TL) has been widely studied in manifold cancer types; however, the results have been inconsistent. This systematic review and meta-analysis aims to analyze the evidence on the association between TL and head and neck cancer (HNC) risk. We comprehensively searched the literature in PubMed, Cochrane Library, and Scopus and identified nine eligible studies, which yielded 11 datasets. The odds ratios (ORs) and 95% confidence intervals (CIs) were used to ascertain the strength of the association. On the basis of the median TL, we defined two groups, short TL and long TL, with the latter being the reference group. Our analysis found a significant relationship between short TL and increased HNC risk (OR 1.38, 95% CI: 1.10-1.73,

Indexed as

Head and Neck NeoplasmsTelomereTelomere HomeostasisHumansOdds RatioRisk Factorsassociationcancerhead and neck cancermeta-analysistelomeretelomere length

Identifiers

PMID39201686
PMCPMC11354702

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.