Evidence map›Paper›PMID 39201633›Full record

ArticleInternational journal of molecular sciences2024

Glutathione-S-Transferase Theta 2 (GSTT2) Modulates the Response to Bacillus Calmette-Guérin Immunotherapy in Bladder Cancer Patients.

Juwita N Rahmat, Sin Mun Tham, Ting Li Ong, Yew Koon Lim, Mugdha Vijay Patwardhan, Lata Raman Nee Mani, Revathi Kamaraj, Yiong Huak Chan, Tsung Wen Chong, Edmund Chiong and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Juwita N RahmatDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.ORCID 0000-0003-4134-0434
Sin Mun ThamDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.ORCID 0000-0001-5136-2894
Ting Li OngSchool of Engineering, Biomedical Engineering, Temasek Polytechnic, Singapore 529757, Singapore.ORCID 0000-0002-9642-0952
Yew Koon LimDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.ORCID 0000-0002-1849-119X
Mugdha Vijay PatwardhanDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.ORCID 0000-0002-0627-8156
Lata Raman Nee ManiDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.
Revathi KamarajDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.ORCID 0000-0002-5694-5631
Yiong Huak ChanBiostatistics Unit, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.ORCID 0000-0002-5076-5269
Tsung Wen ChongDepartment of Urology, Singapore General Hospital, Singapore 169608, Singapore.ORCID 0000-0002-6790-902X
Edmund ChiongDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.
Kesavan EsuvaranathanDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.ORCID 0000-0002-0078-8315
Ratha MahendranDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.ORCID 0000-0002-4359-2160

Funding

Joseph Lim Boon Tiong Urology Cancer Research Initiative A-000-267-600-00National University Health System NUHSRO/2017/059/RO5+5
6 · The paper itself

Abstract

Glutathione-S-transferases (GST) enzymes detoxify xenobiotics and are implicated in response to anticancer therapy. This study evaluated the association of GST theta 1 (GSTT1), GSTT2, and GSTT2B with Mycobacterium bovis Bacillus Calmette-Guérin (BCG) response in non-muscle-invasive bladder cancer treatment. In vitro assessments of GSTT2 knockout (KO) effects were performed using cell lines and dendritic cells (DCs) from GSTT2KO mice. Deletion of GSTT2B, GSTT1, and single-nucleotide polymorphisms in the promoter region of GSTT2 was analysed in patients (

Indexed as

BCG VaccineGlutathione TransferaseImmunotherapyUrinary Bladder NeoplasmsAgedAnimalsCell Line, TumorDendritic CellsFemaleHumansMaleMiceMice, KnockoutMiddle AgedMycobacterium bovisPolymorphism, Single NucleotideBCG Vaccineglutathione S-transferase T1Glutathione TransferaseBCG vaccinebladder cancergeneticglutathione S-transferase theta 2immunotherapypolymorphismurinary bladder neoplasms

Identifiers

PMID39201633
PMCPMC11354831

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.