Evidence map›Paper›PMID 39201604›Full record

ArticleInternational journal of molecular sciences2024

Citrus Flavanone Effects on the Nrf2-Keap1/GSK3/NF-κB/NLRP3 Regulation and Corticotroph-Stress Hormone Loop in the Old Pituitary.

Marko Miler, Jasmina Živanović, Sanja Kovačević, Nevena Vidović, Ana Djordjevic, Branko Filipović, Vladimir Ajdžanović

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. The Lemon Flavonoid EriominInternational journal of molecular sciences · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marko MilerDepartment of Cytology, Institute for Biological Research "Siniša Stanković"-National Institute of the Republic of Serbia, University of Belgrade, 11060 Belgrade, Serbia.ORCID 0000-0002-8366-3138
Jasmina ŽivanovićDepartment of Cytology, Institute for Biological Research "Siniša Stanković"-National Institute of the Republic of Serbia, University of Belgrade, 11060 Belgrade, Serbia.
Sanja KovačevićDepartment of Biochemistry, Institute for Biological Research "Siniša Stanković"-National Institute of the Republic of Serbia, University of Belgrade, 11060 Belgrade, Serbia.ORCID 0000-0002-9854-1934
Nevena VidovićCentre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0001-6931-3695
Ana DjordjevicDepartment of Biochemistry, Institute for Biological Research "Siniša Stanković"-National Institute of the Republic of Serbia, University of Belgrade, 11060 Belgrade, Serbia.ORCID 0000-0002-7042-1631
Branko FilipovićDepartment of Cytology, Institute for Biological Research "Siniša Stanković"-National Institute of the Republic of Serbia, University of Belgrade, 11060 Belgrade, Serbia.
Vladimir AjdžanovićDepartment of Cytology, Institute for Biological Research "Siniša Stanković"-National Institute of the Republic of Serbia, University of Belgrade, 11060 Belgrade, Serbia.ORCID 0000-0002-6540-9603

Funding

Ministry of Science, Innovation and Technological Development of the Republic of Serbia 451-03-66/2024-03/200007
6 · The paper itself

Abstract

Oxidative stress and inflammation are significant causes of aging. At the same time, citrus flavanones, naringenin (NAR), and hesperetin (HES) are bioactives with proven antioxidant and anti-inflammatory properties. Nevertheless, there are still no data about flavanone's influence and its potential effects on the healthy aging process and improving pituitary functioning. Thus, using qPCR, immunoblot, histological techniques, and biochemical assays, our study aimed to elucidate how citrus flavanones (15 mg/kg b.m.

Indexed as

CitrusFlavanonesKelch-Like ECH-Associated Protein 1NF-E2-Related Factor 2NF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinPituitary GlandAdrenocorticotropic HormoneAgingAnimalsAntioxidantsHesperidinMaleOxidative StressRatsRats, WistarAdrenocorticotropic HormoneAntioxidantsFlavanoneshesperetinHesperidinKEAP1 protein, ratKelch-Like ECH-Associated Protein 1naringeninNfe2l2 protein, ratNF-E2-Related Factor 2NF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, ratACTHCATGPxGRhesperetinInterleukin 1 and 6naringeninNLRP3SODTNF-α

Identifiers

PMID39201604
PMCPMC11354440

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.