Evidence map›Paper›PMID 39201581›Full record

ArticleInternational journal of molecular sciences2024

Antibody to Endogenous Cardiotonic Steroid Reverses Vascular Fibrosis and Restores Vasorelaxation in Chronic Kidney Disease.

Natalia I Agalakova, Elena V Mikhailova, Ivan A Ershov, Olga V Nadei, Arseny A Pyankov, Michael M Galagoudza, C David Adair, Irina V Romanova, Alexei Y Bagrov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Natalia I AgalakovaSechenov Institute of Evolutionary Physiology and Biochemistry, 194223 St. Petersburg, Russia.ORCID 0000-0002-0393-8139
Elena V MikhailovaSechenov Institute of Evolutionary Physiology and Biochemistry, 194223 St. Petersburg, Russia.
Ivan A ErshovDepartment of Obstetrics and Gynecology, St. Petersburg State Pediatric Medical University, 194100 St. Petersburg, Russia.
Olga V NadeiSechenov Institute of Evolutionary Physiology and Biochemistry, 194223 St. Petersburg, Russia.
Arseny A PyankovSechenov Institute of Evolutionary Physiology and Biochemistry, 194223 St. Petersburg, Russia.
Michael M GalagoudzaAlmazov National Medical Research Centre, 197341 St. Petersburg, Russia.
C David AdairDepartment of Obstetrics and Gynecology, University of Tennessee College of Medicine, Chattanooga, TN 37403, USA.ORCID 0000-0002-5422-227X
Irina V RomanovaSechenov Institute of Evolutionary Physiology and Biochemistry, 194223 St. Petersburg, Russia.ORCID 0000-0002-0348-0631
Alexei Y BagrovPadakonn Pharma, Puskini 9, 20309 Narva, Estonia.ORCID 0000-0002-2903-8673

Funding

Padakonn Pharma CAESTRU01/2021
6 · The paper itself

Abstract

Marinobufagenin (MBG) is implicated in chronic kidney disease, where it removes Fli1-induced inhibition of the collagen-1. We hypothesized that (i) in nephrectomized rats, aortic fibrosis develops due to elevated plasma MBG and inhibited Fli1, and (ii) that the antibody to MBG reduces collagen-1 and improves vasodilatation. A partial nephrectomy was performed in male Sprague-Dawley rats. Sham-operated animals comprised the control group. At 5 weeks following nephrectomy, rats were administered the vehicle (

Indexed as

BufanolidesFibrosisRats, Sprague-DawleyRenal Insufficiency, ChronicVasodilationAnimalsAntibodiesAortaCollagen Type IEndothelin-1MaleNephrectomyNitroprussideProto-Oncogene Protein c-fli-1RatsAntibodiesBufanolidesCollagen Type IEndothelin-1marinobufageninNitroprussideProto-Oncogene Protein c-fli-1chronic kidney diseasefibrosisFli1marinobufageninNa/K-ATPasevasorelaxation

Identifiers

PMID39201581
PMCPMC11354990

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.