Antibiotics Trigger Host Innate Immune Response via Microbiota-Brain Communication in

Yangyang Wu, Guanqun Li, Hongyun Tang

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yangyang WuCollege of Life Sciences, Zhejiang University, Hangzhou 310058, China.

Guanqun LiKey Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou 310024, China.

Hongyun TangKey Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou 310024, China.

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026

$7.5M

HRHI program of Westlake Laboratory of Life Sciences and Biomedicine 202109007HRHI program of Westlake Laboratory of Life Sciences and Biomedicine 202209003National Key Research and Development Program of China 2019YFA0802900National Natural Science Foundation of China 31871465National Natural Science Foundation of China 32070565National Natural Science Foundation of China 32350015NIH HHS P40 OD010440Westlake Education Foundation of Westlake University and Zhejiang Provincial Key Laboratory Construction Project FundationZhejiang Provincial Natural Science Foundation of China LQ23C040002Zhejiang Provincial Natural Science Foundation of China XHD24C0701

6 · The paper itself

Abstract

Besides their direct bactericidal effect, antibiotics have also been suggested to stimulate the host immune response to defend against pathogens. However, it remains unclear whether any antibiotics may stimulate the host immune response by affecting bacterial activity. In this study, reasoning that genetic mutations inhibit bacterial activities and, thereby, may mimic the effects of antibiotics, we performed genome-wide screening and identified 77

Indexed as

Anti-Bacterial AgentsBrainCaenorhabditis elegansCaenorhabditis elegans ProteinsEscherichia coliImmunity, InnatePseudomonas aeruginosaAnimalsHost-Pathogen InteractionsMicrobiotaMutationAnti-Bacterial AgentsCaenorhabditis elegans ProteinsC. eleganscyp-14A4innate immune responsemicrobiota-brain communicationQ203 antibiotics

Identifiers

PMID39201552

DOI10.3390/ijms25168866

PMCPMC11354627

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.