Evidence map›Paper›PMID 39201532›Full record

ArticleInternational journal of molecular sciences2024

Yuna Kang, Daisuke Nishizawa, Seii Ohka, Takeshi Terui, Kunihiko Ishitani, Ryozo Morino, Miyuki Yokota, Junko Hasegawa, Kyoko Nakayama, Yuko Ebata and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yuna KangAddictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo 156-8506, Japan.
Daisuke NishizawaAddictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo 156-8506, Japan.ORCID 0000-0001-8286-4651
Seii OhkaAddictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo 156-8506, Japan.ORCID 0000-0003-2394-6440
Takeshi TeruiDivision of Internal Medicine, Department of Medicine, Higashi-Sapporo Hospital, Sapporo 003-8585, Japan.ORCID 0000-0002-6166-5335
Kunihiko IshitaniDivision of Internal Medicine, Department of Medicine, Higashi-Sapporo Hospital, Sapporo 003-8585, Japan.ORCID 0000-0001-8420-1608
Ryozo MorinoDivision of Anesthesiology, Koujinkai Daiichi Hospital, Tokyo 125-0041, Japan.
Miyuki YokotaDepartment of Anesthesiology, Cancer Institute Hospital, Tokyo 135-8550, Japan.
Junko HasegawaAddictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo 156-8506, Japan.
Kyoko NakayamaAddictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo 156-8506, Japan.
Yuko EbataAddictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo 156-8506, Japan.
Kyotaro KoshikaDepartment of Neuropsychopharmacology, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo 187-8551, Japan.ORCID 0000-0002-2656-9698
Tatsuya IchinoheDepartment of Neuropsychopharmacology, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo 187-8551, Japan.ORCID 0000-0001-5793-3379
Kazutaka IkedaAddictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo 156-8506, Japan.ORCID 0000-0001-8342-0278

Funding

AdAMS JP22H04922JSPS 23K06839, 20K07774, 20K09259, 17K08970, 21H03028, 17H04324The Japan Agency for Medical Research and Development JP19ek0610011
6 · The paper itself

Abstract

Opioids are almost mandatorily used for analgesia for cancer pain and postoperative pain. Opioid analgesics commonly induce nausea as a side effect. However, the genetic factors involved are still mostly unknown. To clarify the genetic background of individual differences in the occurrence of nausea during opioid administration, the incidence of nausea was investigated in 331 patients (Higashi-Sapporo Hospital [HS] group) who received morphine chronically for cancer pain treatment and in 2021 patients (Cancer Institute Hospital [CIH] group) who underwent elective surgery under general anesthesia. We conducted a genome-wide association study of nausea in HS samples. Among the top 20 candidate single-nucleotide polymorphisms (SNPs), we focused on the

Indexed as

Analgesics, OpioidCancer PainMembrane ProteinsNauseaPolymorphism, Single NucleotidePostoperative PainAdultAgedFemaleGenome-Wide Association StudyGenotypeHumansMaleMiddle AgedMorphineAnalgesics, OpioidMembrane ProteinsMorphineacute phase of opioid usechronic opioid usenauseaSNPTMEM132C

Identifiers

PMID39201532
PMCPMC11354332

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.