Evidence map›Paper›PMID 39201526›Full record

ArticleInternational journal of molecular sciences2024

Preclinical Evaluation of Soluble Epoxide Hydrolase Inhibitor AMHDU against Neuropathic Pain.

Denis Babkov, Natalya Eliseeva, Kristina Adzhienko, Viktoria Bagmetova, Dmitry Danilov, Cynthia B McReynolds, Christophe Morisseau, Bruce D Hammock, Vladimir Burmistrov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The Roles of EETs in Neurological Disorders.CNS neuroscience & therapeutics · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Denis BabkovDepartment of Pharmacology & Bioinformatics, Scientific Center for Innovative Drugs, Volgograd State Medical University, Volgograd 400131, Russia.ORCID 0000-0002-9645-3324
Natalya EliseevaDepartment of Pharmacology & Bioinformatics, Scientific Center for Innovative Drugs, Volgograd State Medical University, Volgograd 400131, Russia.
Kristina AdzhienkoDepartment of Pharmacology & Bioinformatics, Scientific Center for Innovative Drugs, Volgograd State Medical University, Volgograd 400131, Russia.
Viktoria BagmetovaDepartment of Pharmacology & Bioinformatics, Scientific Center for Innovative Drugs, Volgograd State Medical University, Volgograd 400131, Russia.
Dmitry DanilovDepartment of Organic Chemistry, Volgograd State Technical University, Volgograd 400005, Russia.
Cynthia B McReynoldsDepartment of Entomology and Nematology, UC Davis Comprehensive Cancer Center, University of California Davis, Davis, CA 95616, USA.
Christophe MorisseauDepartment of Entomology and Nematology, UC Davis Comprehensive Cancer Center, University of California Davis, Davis, CA 95616, USA.ORCID 0000-0002-5672-6631
Bruce D HammockDepartment of Entomology and Nematology, UC Davis Comprehensive Cancer Center, University of California Davis, Davis, CA 95616, USA.ORCID 0000-0003-1408-8317
Vladimir BurmistrovDepartment of Organic Chemistry, Volgograd State Technical University, Volgograd 400005, Russia.ORCID 0000-0002-8547-9166

Funding

Workshop on Environmental Technology Transfer and EntrepreneurshipP42ES004699 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI YOUNG, THOMAS MICHAEL · 1987 to 2021
$50.1M
Supplement for bioactive lipids as effectors and indicators of the deleterious effects of human healthR35ES030443 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MORISSEAU, CHRISTOPHE HP · 2019 to 2025
$5.8M
Ministry of Health of Russian Federation 124021500036-6NIEHS NIH HHS P42 ES004699NIEHS NIH HHS R35 ES030443Russian Science Foundation 19-73-10002
6 · The paper itself

Abstract

Inhibition of soluble epoxide hydrolase (sEH) is a promising therapeutic strategy for treating neuropathic pain. These inhibitors effectively reduce diabetic neuropathic pain and inflammation induced by Freund's adjuvant which makes them a suitable alternative to traditional opioids. This study showcased the notable analgesic effects of compound

Indexed as

AnalgesicsEpoxide HydrolasesNeuralgiaAdamantaneAnimalsDiabetic NeuropathiesDisease Models, AnimalDrug Evaluation, PreclinicalEdemaEnzyme InhibitorsHyperalgesiaMaleMiceRatsUreaAdamantaneAnalgesicsEnzyme InhibitorsEpoxide HydrolasesUreaadamantaneinhibitorpreclinical evaluationsoluble epoxide hydrolaseurea

Identifiers

PMID39201526
PMCPMC11354909

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.