Evidence map›Paper›PMID 39201483›Full record

ArticleInternational journal of molecular sciences2024

Precision Medicine in Childhood Cancer: The Influence of Genetic Polymorphisms on Vincristine-Induced Peripheral Neuropathy.

Luciana Marangoni-Iglecias, Susana Rojo-Tolosa, Noelia Márquez-Pete, Yasmín Cura, Noelia Moreno-Toro, Cristina Membrive-Jiménez, Almudena Sánchez-Martin, Cristina Pérez-Ramírez, Alberto Jiménez-Morales

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Luciana Marangoni-IgleciasClinical Analysis Laboratory Unit, Hospital Universitário Maria Aparecida Pedrossian HUMAP-UFMS, Av. Sen. Filinto Müler, 355, Vila Ipiranga, Campo Grande 79080-190, Brazil.ORCID 0000-0001-8573-2435
Susana Rojo-TolosaPharmacogenetics Unit, Pharmacy Service, University Hospital Virgen de las Nieves, Avda. de las Fuerzas Armadas 2, 18004 Granada, Spain.ORCID 0000-0001-6930-8933
Noelia Márquez-PetePharmacogenetics Unit, Pharmacy Service, University Hospital Virgen de las Nieves, Avda. de las Fuerzas Armadas 2, 18004 Granada, Spain.
Yasmín CuraPharmacogenetics Unit, Pharmacy Service, University Hospital Virgen de las Nieves, Avda. de las Fuerzas Armadas 2, 18004 Granada, Spain.
Noelia Moreno-ToroPediatric Service, Santa Ana Regional Hospital, Av. Enrique Martín Cuevas, s/n, Motril, 18600 Granada, Spain.ORCID 0000-0002-2508-3338
Cristina Membrive-JiménezPharmacogenetics Unit, Pharmacy Service, University Hospital Virgen de las Nieves, Avda. de las Fuerzas Armadas 2, 18004 Granada, Spain.ORCID 0000-0002-1498-5766
Almudena Sánchez-MartinPharmacogenetics Unit, Pharmacy Service, University Hospital Virgen de las Nieves, Avda. de las Fuerzas Armadas 2, 18004 Granada, Spain.
Cristina Pérez-RamírezPharmacogenetics Unit, Pharmacy Service, University Hospital Virgen de las Nieves, Avda. de las Fuerzas Armadas 2, 18004 Granada, Spain.
Alberto Jiménez-MoralesPharmacogenetics Unit, Pharmacy Service, University Hospital Virgen de las Nieves, Avda. de las Fuerzas Armadas 2, 18004 Granada, Spain.

Funding

Instituto de Salud Carlos III PT13/0010/0039
6 · The paper itself

Abstract

Cancer is the leading cause of disease-related death among children. Vincristine (VCR), a key component of childhood cancer treatment protocols, is associated with the risk of peripheral neuropathy (PN), a condition that may be reversible upon drug discontinuation but can also leave lasting sequelae. Single nucleotide polymorphism (SNP) in genes involved in VCR pharmacokinetics and pharmacodynamics have been investigated in relation to an increased risk of PN. However, the results of these studies have been inconsistent. A retrospective cohort study was conducted to investigate the potential association of drug transporter genes from the ATP-binding cassette (

Indexed as

ATP-Binding Cassette, Sub-Family C ProteinsMultidrug Resistance-Associated Protein 2NeoplasmsPeripheral Nervous System DiseasesPolymorphism, Single NucleotidePrecision MedicineVincristineAdolescentAllelesAntineoplastic Agents, PhytogenicATP Binding Cassette Transporter, Subfamily BCell Cycle ProteinsChildChild, PreschoolFemaleGenetic Predisposition to DiseaseABCB1 protein, humanABCC2 protein, humanAntineoplastic Agents, PhytogenicATP-Binding Cassette, Sub-Family C ProteinsATP Binding Cassette Transporter, Subfamily BCell Cycle ProteinsCEP72 protein, humanMicrotubule-Associated Proteinsmultidrug resistance-associated protein 1Multidrug Resistance-Associated Protein 2Vincristinepediatric oncologyperipheral neuropathypharmacogeneticsprecision medicinetoxicityvincristine

Identifiers

PMID39201483
PMCPMC11354794

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.