ArticleInternational journal of molecular sciences2024
Genetic, Clinical, Epidemiological, and Immunological Profiling of IgG Response Duration after SARS-CoV-2 Infection.
Flávia Póvoa da Costa, Kevin Matheus Lima de Sarges, Rosilene da Silva, Erika Ferreira Dos Santos, Matheus Holanda do Nascimento, Alice Maciel Rodrigues, Marcos Henrique Damasceno Cantanhede, Fabíola Brasil Barbosa Rodrigues, Maria de Nazaré do Socorro de Almeida Viana, Mauro de Meira Leite and 13 more
Abstract read
In one paragraphArticle in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
23 authors.
Flávia Póvoa da CostaLaboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Pará, Brazil.ORCID 0000-0002-5667-0754 Kevin Matheus Lima de SargesLaboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Pará, Brazil.ORCID 0000-0003-0776-6212 Rosilene da SilvaLaboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Pará, Brazil.ORCID 0000-0001-8913-2971 Erika Ferreira Dos SantosLaboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Pará, Brazil.ORCID 0000-0001-9188-1066 Matheus Holanda do NascimentoLaboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Pará, Brazil.ORCID 0009-0007-2807-8159 Alice Maciel RodriguesLaboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Pará, Brazil.ORCID 0009-0002-4927-2835 Marcos Henrique Damasceno CantanhedeLaboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Pará, Brazil.ORCID 0000-0003-2263-8403 Fabíola Brasil Barbosa RodriguesLaboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Pará, Brazil.ORCID 0000-0002-4294-4099 Maria de Nazaré do Socorro de Almeida VianaLaboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Pará, Brazil.
Mauro de Meira LeiteLaboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Pará, Brazil.ORCID 0000-0002-3620-3470 Camille Ferreira de OliveiraSection of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Health Surveillance Secretariat, Brazilian Ministry of Health, Ananindeua 67000-000, Pará, Brazil.ORCID 0000-0003-3859-0061 Pablo Fabiano Moura das NevesCenter of Biological and Health Sciences, State University of Pará, Belém 66050-540, Pará, Brazil.
Gabriel Dos Santos Pereira NetoGraduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Belém 66075-110, Pará, Brazil.ORCID 0000-0002-7825-9384 Mioni Thieli Figueiredo Magalhães de BritoLaboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Pará, Brazil.ORCID 0000-0001-8165-8629 Andréa Luciana Soares da SilvaLaboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Pará, Brazil.ORCID 0000-0003-4299-0252 Daniele Freitas HenriquesSection of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Health Surveillance Secretariat, Brazilian Ministry of Health, Ananindeua 67000-000, Pará, Brazil.
Juarez Antônio Simões QuaresmaCenter of Biological and Health Sciences, State University of Pará, Belém 66050-540, Pará, Brazil.ORCID 0000-0002-6267-9966 Luiz Fábio Magno FalcãoCenter of Biological and Health Sciences, State University of Pará, Belém 66050-540, Pará, Brazil.ORCID 0000-0001-8391-2694 Maria Alice Freitas QueirozGraduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Belém 66075-110, Pará, Brazil.ORCID 0000-0003-2014-2770 Izaura Maria Vieira Cayres VallinotoGraduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Belém 66075-110, Pará, Brazil.
Antonio Carlos Rosário VallinotoGraduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Belém 66075-110, Pará, Brazil.ORCID 0000-0003-1135-6507 Giselle Maria Rachid VianaGraduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Belém 66075-110, Pará, Brazil.
Eduardo José Melo Dos SantosLaboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Pará, Brazil.ORCID 0000-0001-5134-5648 Funding
Amazon Research Foundation #005/2020, #006/2020, #060/2020 and #14/2021Coordenação de Aperfeicoamento de Pessoal de Nível SuperiorNational Council for Scientific and Technological Development #401235/2020-3, #302935/2021-5, #303837/2023-3 and INCT-VER#406360/2022-7Secretaria de Ciência, Tecnologia e Inovação #09/2021
6 · The paper itselfAbstract
The IgG response against SARS-CoV-2 infection can persist for over six months (long response; LR). However, among 30% of those infected, the duration can be as short as three months or less (short response; SR). The present study assembled serological data on the anti-SARS-CoV-2 IgG response duration of two previous studies and integrated these results with the plasmatic cytokine levels and genetic profile of 10 immune-relevant SNPs that were also previously published, along with the plasmatic total IgG, IgA, and IgM levels, allowing for the genetic, clinical, immunological, and epidemiological aspects of the post-COVID-19 IgG response duration to be understood. The SR was associated with previous mild acute COVID-19 and with an SNP (rs2228145) in
Indexed as
Antibodies, ViralCOVID-19Immunoglobulin GPolymorphism, Single NucleotideSARS-CoV-2AdultAgedCytokinesFemaleHumansImmunoglobulin AImmunoglobulin MInterferon-gammaInterleukin-17Interleukin-4MaleAntibodies, ViralCytokinesIL17A protein, humanIL6R protein, humanImmunoglobulin AImmunoglobulin GImmunoglobulin MInterferon-gammaInterleukin-17Interleukin-4Receptors, Interleukin-6antibodiesCOVID-19host geneticsimmunology
Identifiers
PMID39201427
PMCPMC11354850
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