Evidence map›Paper›PMID 39201387›Full record

ArticleInternational journal of molecular sciences2024

One-Step Genetic Modification by Embryonic Doral Aorta Injection of Adenoviral CRISPR/Cas9 Vector in Chicken.

Chao Qin, Shengyao Jiang, Ke Xu, Jianshen Zhu, Liyuan Wang, Wenhao Yang, Fuquan Xiao, Kaixuan Yang, Qizhong Huang, He Meng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chao QinShanghai Key Laboratory of Veterinary Biotechnology, Department of Animal Science, School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, China.ORCID 0009-0003-2566-7119
Shengyao JiangShanghai Key Laboratory of Veterinary Biotechnology, Department of Animal Science, School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, China.
Ke XuShanghai Key Laboratory of Veterinary Biotechnology, Department of Animal Science, School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, China.
Jianshen ZhuShanghai Key Laboratory of Veterinary Biotechnology, Department of Animal Science, School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, China.
Liyuan WangShanghai Key Laboratory of Veterinary Biotechnology, Department of Animal Science, School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, China.
Wenhao YangShanghai Key Laboratory of Veterinary Biotechnology, Department of Animal Science, School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, China.ORCID 0009-0008-6282-0289
Fuquan XiaoShanghai Key Laboratory of Veterinary Biotechnology, Department of Animal Science, School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, China.
Kaixuan YangAnimal Husbandry and Veterinary Research Institute, Shanghai Academy of Agricultural Science, Shanghai 200030, China.
Qizhong HuangAnimal Husbandry and Veterinary Research Institute, Shanghai Academy of Agricultural Science, Shanghai 200030, China.
He MengShanghai Key Laboratory of Veterinary Biotechnology, Department of Animal Science, School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the avian species, genetic modification by cell nuclear transfer is infeasible due to its unique reproductive system. The in vitro primordial germ cell modification approach is difficult and cumbersome, although it is the main method of genetic modification in chickens. In the present study, the adenoviral CRISPR/Cas9 vector was directly microinjected into the dorsal aorta of chicken embryos to achieve in vivo genetic modification. The results demonstrated that

Indexed as

AdenoviridaeAortaChickensCRISPR-Cas SystemsGenetic VectorsAnimalsChick EmbryoGene EditingMaleadenoviruschickenCRISPR/Cas9dorsal aortaKRT75L4

Identifiers

PMID39201387
PMCPMC11354862

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.