Evidence map›Paper›PMID 39201372›Full record

ArticleInternational journal of molecular sciences2024

Brain Region-Specific Expression Levels of Synuclein Genes in an Acid Sphingomyelinase Knockout Mouse Model: Correlation with Depression-/Anxiety-Like Behavior and Locomotor Activity in the Absence of Genotypic Variation.

Razvan-Marius Brazdis, Iulia Zoicas, Johannes Kornhuber, Christiane Mühle

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Razvan-Marius BrazdisDepartment of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, and Friedrich-Alexander University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Iulia ZoicasDepartment of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, and Friedrich-Alexander University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.ORCID 0000-0001-7187-3181
Johannes KornhuberDepartment of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, and Friedrich-Alexander University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.ORCID 0000-0002-8096-3987
Christiane MühleDepartment of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, and Friedrich-Alexander University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.ORCID 0000-0001-7517-9154

Funding

Clinician Scientist Programme within the IZKF, University Hospital Erlangen fellowDeutsche Forschungsgemeinschaft GRK2162/270949263Deutsche Forschungsgemeinschaft KO 947/13Federal Ministry of Education and Research 01EE1401C
6 · The paper itself

Abstract

Accumulating evidence suggests an involvement of sphingolipids, vital components of cell membranes and regulators of cellular processes, in the pathophysiology of both Parkinson's disease and major depressive disorder, indicating a potential common pathway in these neuropsychiatric conditions. Based on this interaction of sphingolipids and synuclein proteins, we explored the gene expression patterns of α-, β-, and γ-synuclein in a knockout mouse model deficient for acid sphingomyelinase (ASM), an enzyme catalyzing the hydrolysis of sphingomyelin to ceramide, and studied associations with behavioral parameters. Normalized

Indexed as

AnxietyBrainDepressionDisease Models, AnimalLocomotionMice, KnockoutSphingomyelin Phosphodiesterasealpha-SynucleinAnimalsBehavior, AnimalFemaleGenotypeMaleMiceMice, Inbred C57BLSynucleinsalpha-SynucleinSphingomyelin PhosphodiesteraseSynucleinsanxiety-like behaviorASMdepression-like behaviorgene expressionknockout micelocomotionSncaSncbSncg

Identifiers

PMID39201372
PMCPMC11354454

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.