Evidence map›Paper›PMID 39201330›Full record

ArticleInternational journal of molecular sciences2024

TFIIB-Termination Factor Interaction Affects Termination of Transcription on Genome-Wide Scale.

Michael J O'Brien, Jared M Schrader, Athar Ansari

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Michael J O'BrienDepartment of Biological Science, 5047 Gullen Mall, Wayne State University, Detroit, MI 48202, USA.
Jared M SchraderDepartment of Biological Science, 5047 Gullen Mall, Wayne State University, Detroit, MI 48202, USA.
Athar AnsariDepartment of Biological Science, 5047 Gullen Mall, Wayne State University, Detroit, MI 48202, USA.ORCID 0000-0003-2806-421X

Funding

A new paradigm of general transcription factor TFIIB functionality in termination and promoter directionalityR01GM146803 · NIGMS · WAYNE STATE UNIVERSITY · PI Athar Imtiaz Ansari · 2022 to 2026
$1.6M
NIGMS NIH HHS R01 GM146803NIH HHS 1R01GM146803-05A1
6 · The paper itself

Abstract

Apart from its well-established role in the initiation of transcription, the general transcription factor TFIIB has been implicated in the termination step as well. The ubiquity of TFIIB involvement in termination as well as mechanistic details of its termination function, however, remain largely unexplored. Using GRO-seq analyses, we compared the terminator readthrough phenotype in the

Indexed as

Transcription Factor TFIIBMutationProtein BindingSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTranscription, GeneticTranscription Termination, GeneticSaccharomyces cerevisiae ProteinsTranscription Factor TFIIBbudding yeastgenome-wide analysesRNA polymerase IITFIIBtranscription

Identifiers

PMID39201330
PMCPMC11354755

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.