Evidence map›Paper›PMID 39201316›Full record

ArticleInternational journal of molecular sciences2024

DNA Damage and Repair in PBMCs after Internal Ex Vivo Irradiation with [

Isabella Strobel, Sarah Schumann, Jessica Müller, Andreas K Buck, Matthias Port, Michael Lassmann, Uta Eberlein, Harry Scherthan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Isabella StrobelDepartment of Nuclear Medicine, University Hospital Würzburg, 97080 Würzburg, Germany.
Sarah SchumannDepartment of Nuclear Medicine, University Hospital Würzburg, 97080 Würzburg, Germany.ORCID 0000-0003-4303-7068
Jessica MüllerBundeswehr Institute of Radiobiology Affiliated to the University of Ulm, 80937 Munich, Germany.
Andreas K BuckDepartment of Nuclear Medicine, University Hospital Würzburg, 97080 Würzburg, Germany.
Matthias PortBundeswehr Institute of Radiobiology Affiliated to the University of Ulm, 80937 Munich, Germany.ORCID 0000-0002-8496-5883
Michael LassmannDepartment of Nuclear Medicine, University Hospital Würzburg, 97080 Würzburg, Germany.ORCID 0000-0002-2556-1977
Uta EberleinDepartment of Nuclear Medicine, University Hospital Würzburg, 97080 Würzburg, Germany.ORCID 0000-0002-2577-3195
Harry ScherthanBundeswehr Institute of Radiobiology Affiliated to the University of Ulm, 80937 Munich, Germany.

Funding

Bundeswehr Medical Service E/U2AD/KA367/KF554
6 · The paper itself

Abstract

The combination of high and low LET radionuclides has been tested in several patient studies to improve treatment response. Radionuclide mixtures can also be released in nuclear power plant accidents or nuclear bomb deployment. This study investigated the DNA damage response and DNA double-strand break (DSB) repair in peripheral blood mononuclear cells (PBMCs) after internal exposure of blood samples of 10 healthy volunteers to either no radiation (baseline) or different radionuclide mixtures of the α- and β-emitters [

Indexed as

DNA DamageDNA RepairLeukocytes, MononuclearAdultDNA Breaks, Double-StrandedFemaleHistonesHumansLutetiumMaleRadioisotopesHistonesLutetiumLutetium-177Radioisotopes53BP1alpha irradiationbeta irradiationDNA damageDNA damage repairdosimetrymixed irradiationradiobiologyγ-H2AX

Identifiers

PMID39201316
PMCPMC11354558

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.