Evidence map›Paper›PMID 39201258›Full record

ArticleInternational journal of molecular sciences2024

Genetic Patterns of Oral Cavity Microbiome in Patients with Sickle Cell Disease.

Faisal Al-Sarraj, Raed Albiheyri, Mohammed Qari, Mohammed Alotaibi, Majid Al-Zahrani, Yasir Anwar, Mashail A Alghamdi, Nada M Nass, Thamer Bouback, Ibrahim Alotibi and 6 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Faisal Al-SarrajDepartment of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0002-5017-3570
Raed AlbiheyriDepartment of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0002-9739-5496
Mohammed QariHematology Department, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Mohammed AlotaibiDepartment of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Majid Al-ZahraniBiological Science Department, College of Science and Art, King Abdulaziz University, Rabigh 21991, Saudi Arabia.ORCID 0000-0003-0781-0121
Yasir AnwarDepartment of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0003-3588-7361
Mashail A AlghamdiDepartment of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Nada M NassDepartment of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0002-7974-1076
Thamer BoubackDepartment of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0001-5918-3807
Ibrahim AlotibiHealth Information Technology Department, Applied College, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0001-5480-6294
Osman RadhwiHematology Department, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0002-1578-3998
Bayan H SajerDepartment of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0002-6687-972X
Alya RedhwanDepartment of Health, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia.ORCID 0000-0002-0602-6442
Mohammed A Al-MataryDepartment of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0009-0002-3129-1261
Enas A AlmanzalawiDepartment of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Hazem S ElshafieDepartment of Agricultural, Forestry, Food and Environmental Sciences (DAFE), University of Basilicata, Via dell'Ateneo Lucano 10, 85100 Potenza, Italy.ORCID 0000-0002-6018-7319

Funding

Deanship of Scientific Research (DSR) at King Abdulaziz University (KAU), Jeddah grant no. J: 007-130-1443.
6 · The paper itself

Abstract

The Middle Eastern prevalence of sickle cell anemia, a genetic disorder that affects red blood cells, necessitates additional research. On a molecular level, we sought to identify and sort the oral microbiota of healthy individuals and those with sickle cell anemia. Furthermore, it is crucial to comprehend how changes in the genetic makeup of the oral microbiota impact the state of sickle cell anemia. Using next-generation sequencing, the 16S rRNA amplicon was examined using saliva samples from 36 individuals with sickle cell anemia and healthy individuals. These samples were obtained from sickle cell anemia patients (18 samples) and healthy control participants (controls, 18 samples). Various analyses are conducted using bioinformatic techniques to identify distinct species and their relative abundance.

Indexed as

Anemia, Sickle CellMicrobiotaMouthRNA, Ribosomal, 16SSalivaAdolescentAdultBacteriaCase-Control StudiesFemaleHigh-Throughput Nucleotide SequencingHumansMaleMiddle AgedYoung AdultRNA, Ribosomal, 16Smetagenomicsnext-generation sequencingsickle cell anemiasystemic diseases

Identifiers

PMID39201258
PMCPMC11354819

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.