Evidence map›Paper›PMID 39201053›Full record

ReviewJournal of clinical medicine2024

Innovations in Early Lung Cancer Detection: Tracing the Evolution and Advancements in Screening.

Lindsey B Cotton, Peter B Bach, Chris Cisar, Caitlin A Schonewolf, Demetria Tennefoss, Anil Vachani, Lisa Carter-Bawa, Ali H Zaidi

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lindsey B CottonDELFI Diagnostics, Inc., Baltimore, MD 21224, USA.ORCID 0009-0001-4736-6160
Peter B BachDELFI Diagnostics, Inc., Baltimore, MD 21224, USA.ORCID 0000-0001-5175-402X
Chris CisarDELFI Diagnostics, Inc., Baltimore, MD 21224, USA.ORCID 0009-0002-2936-5129
Caitlin A SchonewolfDELFI Diagnostics, Inc., Baltimore, MD 21224, USA.
Demetria TennefossDELFI Diagnostics, Inc., Baltimore, MD 21224, USA.
Anil VachaniPulmonary, Allergy, and Critical Care Division, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.ORCID 0000-0002-3871-8697
Lisa Carter-BawaCenter for Discovery & Innovation at Hackensack Meridian Health, Cancer Prevention Precision Control Institute, Nutley, NJ 07110, USA.ORCID 0000-0002-6448-6033
Ali H ZaidiAllegheny Health Network Cancer Institute, Pittsburgh, PA 15224, USA.ORCID 0000-0002-5463-2252

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung cancer mortality rates, particularly non-small cell lung cancer (NSCLC), continue to present a significant global health challenge, and the adoption of lung cancer screening remains limited, often influenced by inequities in access to healthcare. Despite clinical evidence demonstrating the efficacy of annual screening with low-dose computed tomography (LDCT) and recommendations from medical organizations including the U.S. Preventive Services Task Force (USPSTF), the national lung cancer screening uptake remains around 5% among eligible individuals. Advancements in the clinical management of NSCLC have recently become more personalized with the implementation of blood-based biomarker testing. Extensive research into tumor-derived cell-free DNA (cfDNA) through fragmentation offers a novel method for improving early lung cancer detection. This review assesses the screening landscape, explores obstacles to lung cancer screening, and discusses how a plasma whole genome fragmentome test (pWGFrag-Lung) can improve lung cancer screening participation and adherence.

Indexed as

blood-based testingcell-free DNADELFIfragmentomicsliquid biopsylow-dose computed tomographylung cancer screeningNSCLCscreening adherenceUSPSTF

Identifiers

PMID39201053
PMCPMC11355097

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.