Evidence map›Paper›PMID 39200278›Full record

ArticleBiomedicines2024

β-Adrenoceptor Agonists Attenuate Thrombin-Induced Impairment of Human Lung Endothelial Cell Barrier Function and Protect the Lung Vascular Barrier during Resuscitation from Hemorrhagic Shock.

Michelle Y McGee, Ololade Ogunsina, Sadia N Boshra, Xianlong Gao, Matthias Majetschak

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Michelle Y McGeeDepartment of Surgery, University of South Florida Morsani College of Medicine, Tampa, FL 33612, USA.
Ololade OgunsinaDepartment of Surgery, University of South Florida Morsani College of Medicine, Tampa, FL 33612, USA.
Sadia N BoshraDepartment of Surgery, University of South Florida Morsani College of Medicine, Tampa, FL 33612, USA.ORCID 0009-0002-3013-3245
Xianlong GaoDepartment of Surgery, University of South Florida Morsani College of Medicine, Tampa, FL 33612, USA.
Matthias MajetschakDepartment of Surgery, University of South Florida Morsani College of Medicine, Tampa, FL 33612, USA.

Funding

Contributions of vascular chemokine receptors to cardiovascular function after traumatic-hemorrhagic shockR01GM139811 · NIGMS · UNIVERSITY OF SOUTH FLORIDA · PI MAJETSCHAK, MATTHIAS · 2020 to 2023
$1.7M
Regulation of vascular function after traumatic-hemorrhagic shock and during inflammationR35GM152056 · NIGMS · UNIVERSITY OF SOUTH FLORIDA · PI Matthias Majetschak · 2024 to 2026
$938k
NIGMS NIH HHS R01 GM139811NIGMS NIH HHS R35 GM152056NIH HHS R01GM139811NIH HHS R35GM152056
6 · The paper itself

Abstract

β-adrenoceptor (β-AR) agonists are known to antagonize thrombin-induced impairment (TII) of bovine and ovine lung endothelial barrier function. The effects of adrenoceptor agonists and other vasoactive agents on human lung microvascular endothelial cell (HULEC-5a) barrier function upon thrombin exposure have not been studied. Furthermore, it is unknown whether the in vitro effects of adrenoceptor agonists translate to lung protective effects in vivo. We observed that epinephrine, norepinephrine, and phenylephrine enhanced normal and prevented TII of HULEC-5a barrier function. Arginine vasopressin and angiotensin II were ineffective. α

Indexed as

adrenoceptor agonistsEvans blue extravasationlung vascular barrier functionthrombinβ-adrenergic receptors

Identifiers

PMID39200278
PMCPMC11352179

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.