Unveiling a Dermatological Rarity: The Enigma of Vulvar Intraepithelial Neoplasia Grade III (HSIL) and the Role of p53 in Its Development.

Piotr Brzeziński, Igor Feszak, Beatriz Di Martino Ortiz, Sylwia Feszak, Piotr Kawczak, Tomasz Bączek

Abstract readCase Reports

In one paragraph

Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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5 · Who and what money

Authors and funding

6 authors.

Piotr BrzezińskiInstitute of Health Sciences, Pomeranian University in Słupsk, 76-200 Słupsk, Poland.

Igor FeszakInstitute of Health Sciences, Pomeranian University in Słupsk, 76-200 Słupsk, Poland.ORCID 0000-0003-0719-1754

Beatriz Di Martino OrtizDermatology Department, Clinicas Hospital, Faculty of Medical Sciences, National University of Ausunción, San Lorenzo 111421, Paraguay.

Sylwia FeszakDepartment of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland.

Piotr KawczakDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University of Gdańsk, 80-416 Gdańsk, Poland.ORCID 0000-0003-3902-2744

Tomasz BączekDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University of Gdańsk, 80-416 Gdańsk, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vulvar intraepithelial neoplasia, also known as VIN, is a non-invasive squamous lesion and precursor of squamous cell carcinoma (SCC) of the vulva. There is no screening test for vulvar intraepithelial neoplasia. Diagnosis of VIN is made clinically and confirmed with a biopsy. We describe a 66-year-old woman with a condyloma-like tumour located in the skin on the vestibule of the vagina. A biopsy sample was taken from the nodule. The definitive diagnosis is supported by the histological examination (VIN III) and immunohistochemical examination of p16(+), p53(+), and a few cell nuclei. The case provides information on the importance of multidisciplinary cooperation. Lifelong surveillance is essential since the resection of individual lesions does not guarantee the prevention of invasive cancer.

Indexed as

differentiated vulvar intraepithelial neoplasiaHPVp16p53vulvar cancer

Identifiers

PMID39200263

DOI10.3390/biomedicines12081799

PMCPMC11351730

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