Evidence map›Paper›PMID 39200089›Full record

ArticleAntibiotics (Basel, Switzerland)2024

Combinatory Use of hLF(1-11), a Synthetic Peptide Derived from Human Lactoferrin, and Fluconazole/Amphotericin B against

Carlo P J M Brouwer, Bart Theelen, Youp van der Linden, Nick Sarink, Mahfuzur Rahman, Saleh Alwasel, Claudia Cafarchia, Mick M Welling, Teun Boekhout

Abstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Antimicrobial peptides: from discovery to developmental applications.Applied and environmental microbiology · 2025
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Carlo P J M BrouwerCBMR Scientific Inc., Edmonton, AB T6J4V9, Canada.
Bart TheelenWesterdijk Fungal Biodiversity Institute, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.ORCID 0000-0003-1333-2058
Youp van der LindenWesterdijk Fungal Biodiversity Institute, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.
Nick SarinkWesterdijk Fungal Biodiversity Institute, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.
Mahfuzur RahmanCBMR Scientific Inc., Edmonton, AB T6J4V9, Canada.
Saleh AlwaselCollege of Sciences, King Saud University, Riyadh 11451, Saudi Arabia.
Claudia CafarchiaDipartimento di Medicina Veterinaria, Università degli Studi "Aldo Moro", 70121 Bari, Italy.ORCID 0000-0002-5632-4472
Mick M WellingInterventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.ORCID 0000-0002-2249-5601
Teun BoekhoutWesterdijk Fungal Biodiversity Institute, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe increasing resistance of

methodsIn the current study, we tested the antimicrobial susceptibility of 30 strains of

resultshLF(1-11) inhibited the growth of all species tested, resulting in minimum inhibitory concentrations (MIC) values ranging from 12.5 to 100 μg/mL. In the combinatory tests, the majority of fractional inhibitory concentration indexes (FIC) for the tested strains of

conclusionResults showed that hLF(1-11) could be combined with fluconazole or amphotericin for the antimicrobial treatment of resistant strains, enhancing the potency of these antifungal drugs, resulting in an improved outcome for the patient.

Indexed as

antifungalshLF(1-11)lactoferrinMalasseziapeptidesynergytreatment

Identifiers

PMID39200089
PMCPMC11351325

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.