Evidence map›Paper›PMID 39200038›Full record

ArticleAntibiotics (Basel, Switzerland)2024

Detection of Pharmaceutical Contamination in Amphipods of Lake Baikal by the HPLC-MS Method.

Tamara Y Telnova, Maria M Morgunova, Sophie S Shashkina, Anfisa A Vlasova, Maria E Dmitrieva, Victoria N Shelkovnikova, Ekaterina V Malygina, Natalia A Imidoeva, Alexander Y Belyshenko, Alexander S Konovalov and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Development of anBiosensors · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tamara Y TelnovaResearch Department, Biological and Soil Faculty, Irkutsk State University, Irkutsk 664003, Russia.ORCID 0000-0003-2606-3766
Maria M MorgunovaResearch Department, Biological and Soil Faculty, Irkutsk State University, Irkutsk 664003, Russia.ORCID 0000-0002-7939-1432
Sophie S ShashkinaResearch Department, Biological and Soil Faculty, Irkutsk State University, Irkutsk 664003, Russia.ORCID 0000-0002-3378-5671
Anfisa A VlasovaResearch Department, Biological and Soil Faculty, Irkutsk State University, Irkutsk 664003, Russia.ORCID 0000-0002-7817-5156
Maria E DmitrievaResearch Department, Biological and Soil Faculty, Irkutsk State University, Irkutsk 664003, Russia.ORCID 0000-0002-9229-1954
Victoria N ShelkovnikovaResearch Department, Biological and Soil Faculty, Irkutsk State University, Irkutsk 664003, Russia.ORCID 0000-0002-4411-7521
Ekaterina V MalyginaResearch Department, Biological and Soil Faculty, Irkutsk State University, Irkutsk 664003, Russia.ORCID 0000-0002-2673-0226
Natalia A ImidoevaResearch Department, Biological and Soil Faculty, Irkutsk State University, Irkutsk 664003, Russia.ORCID 0000-0002-6327-5517
Alexander Y BelyshenkoResearch Department, Biological and Soil Faculty, Irkutsk State University, Irkutsk 664003, Russia.ORCID 0000-0002-8812-2250
Alexander S KonovalovResearch Department, Biological and Soil Faculty, Irkutsk State University, Irkutsk 664003, Russia.ORCID 0000-0003-0723-0370
Evgenia A MisharinaResearch Department, Biological and Soil Faculty, Irkutsk State University, Irkutsk 664003, Russia.
Denis V Axenov-GribanovResearch Department, Biological and Soil Faculty, Irkutsk State University, Irkutsk 664003, Russia.ORCID 0000-0003-2020-6084

Funding

Ministry of Higher Education and Science of the Russian Federation FZZE 2024-0003Ministry of Higher Education and Science of the Russian Federation FZZE 2024-0011
6 · The paper itself

Abstract

Pollution by active ingredients is one of the most significant and widespread forms of pollution on Earth. Medicines can have a negative impact on ecosystems, and contamination can have unpredictable consequences. An urgent and unexplored task is to study the Lake Baikal ecosystem and its organisms for the presence of trace concentrations of active pharmaceutical ingredients. Our study aimed to conduct a qualitative analysis of active pharmaceutical ingredients, and quantitative analysis of ibuprofen in endemic amphipods of Lake Baikal, using methods of high-performance liquid chromatography and mass spectrometry (HPLC-MS). Acetylsalicylic acid (aspirin), ibuprofen, acetaminophen, azithromycin, dimetridazole, metronidazole, amikacin, spiramycin, and some tetracycline antibiotics were detected in the studied littoral amphipods. We also detected different annual loads of active pharmaceutical ingredients on amphipods. Using the multiple reaction monitoring (MRM) mode mentioned in GOST International Technical Standards, we detected molecules, fragmented as amikacin, chlortetracycline, doxycycline, oxytetracycline, dimetridazole, metronidazole and spiramycin. Thus, we first revealed that invertebrates of Lake Baikal can uptake pharmaceutical contaminants in the environment.

Indexed as

amphipodsantibioticsBaikalendemicsHPLC-MSibuprofenpharmaceutical pollution

Identifiers

PMID39200038
PMCPMC11350909

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.