ArticleAntibiotics (Basel, Switzerland)2024
Local Antimicrobial Therapy with Combined Aminoglycoside and Vancomycin Compared to Aminoglycoside Monotherapy in the Surgical Management of Osteomyelitis and Fracture-Related Infection.
Article in Antibiotics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Current and emerging antibacterial strategies for periprosthetic joint infection: An overview.Bioactive materials · 2026Review
- Diagnosis and management of fracture-related infections in a low-income country: a prospective study comparing current practice to international consensus guidelines.Journal of bone and joint infection · 2026Article
- Gentamicin fails to eradicateJournal of bone and joint infection · 2026Article
- Management of fracture-related infection in low-resource settings in Africa: recommendations and guidelines from an international expert group.Journal of bone and joint infection · 2026Article
- Cementless one-stage hip revision arthroplasty with an injectable antibiotic bone graft substitute : a pilot study.Bone & joint open · 2025Article
- Single- versus two-stage revision surgery in the case of fracture-related infection: a systematic review.Journal of bone and joint infection · 2025Review
- A Comparison of Causative Pathogens in Bone and Prosthetic Joint Infections: Implications for Antimicrobial Therapy.Antibiotics (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
We investigated the effect of combination aminoglycoside and vancomycin local antibiotic treatment compared to aminoglycoside alone in the surgical management of bone infection. Data including patient demographics, type of surgery, microbiological characteristics, BACH score, duration of antibiotic treatment and clinical outcomes were collected. Failure of therapy was a composite of recurrence of infection, continued or new antimicrobial therapy, or reoperation with suspected or confirmed infection at one year after index surgery. A total of 266 patients met the inclusion criteria. 252 patients reached the final follow-up and were included in the final analysis. 113 patients had treatment with aminoglycoside alone and 139 patients had combination aminoglycoside and vancomycin. There was no difference in the failure rate between groups; 10/113 (8.8%) in the aminoglycoside alone and 12/139 (8.6%) in the combination group,
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