Evidence map›Paper›PMID 39199957›Full record

ArticleAnimals : an open access journal from MDPI2024

Study on the Regulatory Mechanism of the PDK1-Mediated TGF-β/Smad Signaling Pathway in Hypoxia-Induced Yak Lungs.

Yiyang Zhang, Jun Wang, Meng Zhang, Xiaoyun Li, Fan Zhang, Manlin Zhou, Kun Yang, Weiji Chen, Haie Ding, Xiao Tan and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yiyang ZhangEngineering Research Center of Key Technology and Industrialization of Cell-Based Vaccine, Ministry of Education, Northwest Minzu University, Lanzhou 730030, China.
Jun WangLife Science and Engineering College, Northwest Minzu University, Lanzhou 730030, China.
Meng ZhangLife Science and Engineering College, Northwest Minzu University, Lanzhou 730030, China.
Xiaoyun LiEngineering Research Center of Key Technology and Industrialization of Cell-Based Vaccine, Ministry of Education, Northwest Minzu University, Lanzhou 730030, China.
Fan ZhangEngineering Research Center of Key Technology and Industrialization of Cell-Based Vaccine, Ministry of Education, Northwest Minzu University, Lanzhou 730030, China.
Manlin ZhouEngineering Research Center of Key Technology and Industrialization of Cell-Based Vaccine, Ministry of Education, Northwest Minzu University, Lanzhou 730030, China.
Kun YangEngineering Research Center of Key Technology and Industrialization of Cell-Based Vaccine, Ministry of Education, Northwest Minzu University, Lanzhou 730030, China.
Weiji ChenLife Science and Engineering College, Northwest Minzu University, Lanzhou 730030, China.
Haie DingLife Science and Engineering College, Northwest Minzu University, Lanzhou 730030, China.
Xiao TanLife Science and Engineering College, Northwest Minzu University, Lanzhou 730030, China.
Qian ZhangCollege of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China.
Zilin QiaoEngineering Research Center of Key Technology and Industrialization of Cell-Based Vaccine, Ministry of Education, Northwest Minzu University, Lanzhou 730030, China.

Funding

Gansu Province Education Science and Technology Innovation Programme 2023B-055Lanzhou Youth Science and Technology Talent Innovation Program 2023QN-7CNational Natural Science Foundation of China 31860687, 32002241Natural Science Foundation of Gansu Province 24JRRA155Supported by Fundamental Research Funds for the Central Universities 31920230060, 31920230152, 31920230158
6 · The paper itself

Abstract

The aim of this study was to investigate the effects of hypoxia-induced phenotype, glucose metabolism, ROS levels, and the PDK1-mediated regulation of TGF-β/Smad signaling in yellow cattles, yaks, and those overexpressing PDK1 PASMCs using growth curves, flow cytometry, scratch experiments, glucose and lactic acid assays, RT-qPCR, and Western blotting. The results showed that hypoxia significantly promoted proliferation, migration, antiapoptosis, ROS levels, glucose consumption, and lactate production in yellow cattle PASMCs (

Indexed as

hypoxiapulmonary artery smooth muscle cells (PASMCs)pyruvate dehydrogenase kinase 1 (PDK1)TGF-β/Smad signaling pathwayyakyellow cattle

Identifiers

PMID39199957
PMCPMC11350703

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.