ArticleBioengineering (Basel, Switzerland)2024
In Vivo Testing of a Second-Generation Prototype Accessory for Single Transapical Left Ventricular Assist Device Implantation.
Article in Bioengineering (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The trial behind it
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Who cites it
4 citing papers in PubMed.
- Exploratory proof-of-concept study and failure mode analysis of a dual-lumen stent graft for transapical off-pump LVAD implantation.Scientific reports · 2026Article
- Survival prognosis and clinical experience of HeartCon-type left ventricular assist device implantation for treating patients with end-stage heart failure: a single-center retrospective study from China.Journal of thoracic disease · 2025Article
- Minimally invasive, transapical dual-lumened cannula for short-term left ventricular support in a clinically relevant large animal model†.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2025Article
- In silico analysis of pressure distribution and flow profiles across an experimental left ventricular assist device accessory.Interdisciplinary cardiovascular and thoracic surgery · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
A new accessory was developed to allow implantation of left ventricular assist devices (LVADs) without requiring an anastomosis to the ascending aorta. The accessory combines the LVAD inflow and outflow into a dual-lumen device. Initial prototypes encountered reduced pump performance in vitro, but a second-generation prototype successfully addressed this issue. This feasibility study aimed to demonstrate the anatomic fit, safe implantation, and hemodynamic effectiveness of the LVAD with the accessory. The accessory was implanted in ten female pigs (104 ± 13 kg). Following sternotomy and apical coring under cardiopulmonary bypass, a balloon catheter was retrogradely inserted and exteriorized through the coring site, where it was inflated within the distal third of the outflow graft. It was utilized to pull the accessory's outflow across the aortic valve. After LVAD attachment, the catheter was removed. Echocardiography revealed no relevant valve regurgitation post-implantation. During ramp testing, pump flow increased from 3.7 ± 1.2 to 5.4 ± 1.2 L/min. Necropsy confirmed correct accessory placement in nine animals. No valve lesions or device thrombosis were observed. The accessory enabled LVAD implantation without compromising pump performance. Future work includes design refinements for implantation without cardiopulmonary bypass and long-term testing in a chronic heart failure model.
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Registered trials
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