Evidence map›Paper›PMID 39199667›Full record

ArticleCancers2024

Tumor-Infiltrating Lymphocyte Scoring in Neoadjuvant-Treated Breast Cancer.

Noémie Thomas, Soizic Garaud, Mireille Langouo, Doïna Sofronii, Anaïs Boisson, Alexandre De Wind, Valérie Duwel, Ligia Craciun, Dennis Larsimont, Ahmad Awada and 1 more

Abstract read
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Digital pathology in tau research: A comparison of QuPath and HALO.Journal of neuropathology and experimental neurology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Noémie ThomasMolecular Immunology Unit, Institut Jules Bordet, 1070 Brussels, Belgium.ORCID 0000-0002-9259-8120
Soizic GaraudMolecular Immunology Unit, Institut Jules Bordet, 1070 Brussels, Belgium.
Mireille LangouoMolecular Immunology Unit, Institut Jules Bordet, 1070 Brussels, Belgium.
Doïna SofroniiMolecular Immunology Unit, Institut Jules Bordet, 1070 Brussels, Belgium.
Anaïs BoissonMolecular Immunology Unit, Institut Jules Bordet, 1070 Brussels, Belgium.
Alexandre De WindAnantomical Pathology Department, Institut Jules Bordet, 1070 Brussels, Belgium.
Valérie DuwelAnatomical Pathology Department, AZ Klina, 2930 Brasschaat, Belgium.
Ligia CraciunAnantomical Pathology Department, Institut Jules Bordet, 1070 Brussels, Belgium.
Dennis LarsimontAnantomical Pathology Department, Institut Jules Bordet, 1070 Brussels, Belgium.
Ahmad AwadaMedical Oncology, Institut Jules Bordet, 1070 Brussels, Belgium.
Karen Willard-GalloMolecular Immunology Unit, Institut Jules Bordet, 1070 Brussels, Belgium.ORCID 0000-0002-1150-1295

Funding

Association Jules Bordet NACancer Plan of Belgium KPC_29_048Fondation Lambeaux-Marteaux NAFund for Scientific Research 7.6522.20FMEDIC Foundation NA
6 · The paper itself

Abstract

Neoadjuvant chemotherapy (NAC) is now the standard of care for patients with locally advanced breast cancer (BC). TIL scoring is prognostic and adds predictive value to the residual cancer burden evaluation after NAC. However, NAC induces changes in the tumor, and the reliability of TIL scoring in post-NAC samples has not yet been studied. H&E- and dual CD3/CD20 chromogenic IHC-stained tissues were scored for stromal and intra-tumoral TIL by two experienced pathologists on pre- and post-treatment BC tissues. Digital TIL scoring was performed using the HALO

Indexed as

breast cancerdigital pathologyimmune biomarkerslymphoid aggregatesneoadjuvant chemotherapytertiary lymphoid structurestumor-infiltrating lymphocytes

Identifiers

PMID39199667
PMCPMC11352458

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.