Evidence map›Paper›PMID 39199643›Full record

ArticleCancers2024

Comparative Analysis of Repeatability in CT Radiomics and Dosiomics Features under Image Perturbation: A Study in Cervical Cancer Patients.

Zongrui Ma, Jiang Zhang, Xi Liu, Xinzhi Teng, Yu-Hua Huang, Xile Zhang, Jun Li, Yuxi Pan, Jiachen Sun, Yanjing Dong and 7 more

Abstract read
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Redefining breast cancer: therapeutic opportunities in HER2-low and emerging molecular subtypes.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Zongrui MaDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China.
Jiang ZhangDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China.ORCID 0000-0001-5807-1686
Xi LiuDepartment of Radiation Oncology, Cancer Center, Peking University Third Hospital, Beijing 100191, China.ORCID 0009-0009-6924-4525
Xinzhi TengDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China.ORCID 0000-0001-7515-8302
Yu-Hua HuangDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China.ORCID 0000-0001-9610-2113
Xile ZhangDepartment of Radiation Oncology, Cancer Center, Peking University Third Hospital, Beijing 100191, China.
Jun LiDepartment of Radiation Oncology, Cancer Center, Peking University Third Hospital, Beijing 100191, China.
Yuxi PanDepartment of Radiation Oncology, Cancer Center, Peking University Third Hospital, Beijing 100191, China.
Jiachen SunDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China.
Yanjing DongDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China.
Tian LiDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China.
Lawrence Wing Chi ChanDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China.ORCID 0000-0001-6451-2273
Amy Tien Yee ChangComprehensive Oncology Centre, Hong Kong Sanatorium & Hospital, Hong Kong, China.
Steven Wai Kwan SiuDepartment of Clinical Oncology, Queen Mary Hospital, Hong Kong, China.
Andy Lai-Yin CheungDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China.
Ruijie YangDepartment of Radiation Oncology, Cancer Center, Peking University Third Hospital, Beijing 100191, China.
Jing CaiDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China.ORCID 0000-0001-6934-0108

Funding

Beijing Municipal Commission of Science and Technology Collaborative Innovation Project Z221100003522028Beijing Natural Science Foundation Z230003Health and Medical Research Fund HMRF 09200576Mainland-Hong Kong Joint Funding Scheme (MHKJFS) MHP/005/20The National Key Research and Development Program No. 2021YFE0202500
6 · The paper itself

Abstract

This study aims to evaluate the repeatability of radiomics and dosiomics features via image perturbation of patients with cervical cancer. A total of 304 cervical cancer patients with planning CT images and dose maps were retrospectively included. Random translation, rotation, and contour randomization were applied to CT images and dose maps before radiomics feature extraction. The repeatability of radiomics and dosiomics features was assessed using intra-class correlation of coefficient (ICC). Pearson correlation coefficient (r) was adopted to quantify the correlation between the image characteristics and feature repeatability. In general, the repeatability of dosiomics features was lower compared with CT radiomics features, especially after small-sigma Laplacian-of-Gaussian (LoG) and wavelet filtering. More repeatable features (ICC > 0.9) were observed when extracted from the original, Large-sigma LoG filtered, and LLL-/LLH-wavelet filtered images. Positive correlations were found between image entropy and high-repeatable feature number in both CT and dose (r = 0.56, 0.68). Radiomics features showed higher repeatability compared to dosiomics features. These findings highlight the potential of radiomics features for robust quantitative imaging analysis in cervical cancer patients, while suggesting the need for further refinement of dosiomics approaches to enhance their repeatability.

Indexed as

cervical cancerdosiomicsimage perturbationquantitative imaging analysisradiomicsrepeatability

Identifiers

PMID39199643
PMCPMC11352227

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.