Evidence map›Paper›PMID 39199591›Full record

ArticleCancers2024

Detection of Hepatocellular Carcinoma in an Orthotopic Patient-Derived Xenograft with an Epithelial Cell Adhesion Molecule-Specific Peptide.

Xiaoli Wu, Shuo Feng, Tse-Shao Chang, Ruoliu Zhang, Sangeeta Jaiswal, Eun-Young K Choi, Yuting Duan, Hui Jiang, Thomas D Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaoli WuDepartment of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI 48109, USA.
Shuo FengDepartment of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-7111-8899
Tse-Shao ChangDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-1787-8744
Ruoliu ZhangDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Sangeeta JaiswalDepartment of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI 48109, USA.
Eun-Young K ChoiDepartment of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
Yuting DuanDepartment of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
Hui JiangDepartment of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-2718-9811
Thomas D WangDepartment of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-9182-9620

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Eric R. Fearon · 1988 to 2026
$178.2M
NOVEL STRATEGIES TO IMPROVE LIVER CANCER SURVEILLANCE UPTAKE AND EARLY DETECTIONU01CA230669 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LOK, ANNA S.F., SU, GRACE L. · 2018 to 2022
$3.3M
NCI NIH HHS P30 CA046592NIH HHS U01 CA230669
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) has emerged as a major contributor to the worldwide cancer burden. Improved methods are needed for early cancer detection and image-guided surgery. Peptides have small dimensions that can overcome delivery challenges to achieve high tumor concentrations and deep penetration. We used phage display methods to biopan against the extra-cellular domain of the purified EpCAM protein, and used IRDye800 as a near-infrared (NIR) fluorophore. The 12-mer sequence HPDMFTRTHSHN was identified, and specific binding to EpCAM was validated with HCC cells in vitro. A binding affinity of k

Indexed as

EpCAMfluorescencehepatocellular carcinomaimagingnear infraredpeptide

Identifiers

PMID39199591
PMCPMC11352241

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.