Evidence map›Paper›PMID 39199529›Full record

ArticleBrain sciences2024

Spontaneously Hypertensive Rats Present Exacerbated Focal Stroke Behavioral Outcomes.

João Victor Matos E Moreira, Luis Pedro Bernardi, Fernanda Cardoso Teixeira, Jerônimo Paniago, Luciele Varaschini Teixeira, Felippo Bifi, Diogo Onofre Souza, Francieli Rohden

Abstract read
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In one paragraph

Article in Brain sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

João Victor Matos E MoreiraGraduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Annex Building, Ramiro Barcelos Street 2600, Porto Alegre 90035-003, Rio Grande do Sul, Brazil.
Luis Pedro BernardiGraduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Annex Building, Ramiro Barcelos Street 2600, Porto Alegre 90035-003, Rio Grande do Sul, Brazil.ORCID 0000-0001-7119-1076
Fernanda Cardoso TeixeiraGraduate Program in Biosciences, Federal University of Health Sciences of Porto Alegre-UFCSPA, Porto Alegre 90050-170, Rio Grande do Sul, Brazil.
Jerônimo PaniagoGraduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Annex Building, Ramiro Barcelos Street 2600, Porto Alegre 90035-003, Rio Grande do Sul, Brazil.ORCID 0000-0001-8217-6939
Luciele Varaschini TeixeiraGraduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Annex Building, Ramiro Barcelos Street 2600, Porto Alegre 90035-003, Rio Grande do Sul, Brazil.
Felippo BifiGraduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Annex Building, Ramiro Barcelos Street 2600, Porto Alegre 90035-003, Rio Grande do Sul, Brazil.ORCID 0000-0002-8921-6638
Diogo Onofre SouzaGraduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Annex Building, Ramiro Barcelos Street 2600, Porto Alegre 90035-003, Rio Grande do Sul, Brazil.
Francieli RohdenGraduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Annex Building, Ramiro Barcelos Street 2600, Porto Alegre 90035-003, Rio Grande do Sul, Brazil.ORCID 0000-0002-9232-7371

Funding

CNPQ/INCT 465671/2014-4
6 · The paper itself

Abstract

This study aimed to analyze the effects of systemic arterial hypertension (SAH) in a model of permanent ischemic stroke (focal ischemia due to thermocoagulation of pial vessels) on sensorimotor function (cylinder test and patch removal test), behavioral tasks (novelty habituation memory open field task) and cerebral infarct size in adult male spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY) for 42 days after the occurrence of a stroke. We observed that the stroke caused asymmetry in the front paws and delayed adhesive removal. These effects were spontaneously reduced in WKY rats, but not in SHR. Short- and long-term novelty habituation memories were abolished by stroke in WYK and SHR. On the 3rd day after stroke, the size of the focal cerebral infarct was the same in WKY and SHR. However, on the 7th day, the infarct size decreased in WKY rats, but not SHR. These results suggested that SAH impairment of sensorimotor recovery in rats subjected to cerebral ischemia could be related to augmented focal cerebral infarct size. Moreover, the behavioral tasks used in this study were unaffected by Systemic Arterial Hypertension. Our results highlight the need for animal models of comorbidities in stroke research.

Indexed as

ischemic strokememoryratssensorimotorsystemic arterial hypertension

Identifiers

PMID39199529
PMCPMC11352869

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.