Evidence map›Paper›PMID 39199364›Full record

ArticleBiomolecules2024

DNA Methylation of

Susanne Edelmann, Jeysri Balaji, Sarah Pasche, Ariane Wiegand, Vanessa Nieratschker

Abstract read
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. InvestigatingBrain sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Susanne EdelmannDepartment of Psychiatry and Psychotherapy, University Hospital of Tuebingen, Eberhard Karls University of Tuebingen, 72076 Tuebingen, Germany.
Jeysri BalajiDepartment of Psychiatry and Psychotherapy, University Hospital of Tuebingen, Eberhard Karls University of Tuebingen, 72076 Tuebingen, Germany.
Sarah PascheDepartment of Psychiatry and Psychotherapy, University Hospital of Tuebingen, Eberhard Karls University of Tuebingen, 72076 Tuebingen, Germany.
Ariane WiegandMax Planck Fellow Group Precision Psychiatry, Max Planck Institute of Psychiatry, 80804 Munich, Germany.
Vanessa NieratschkerDepartment of Psychiatry and Psychotherapy, University Hospital of Tuebingen, Eberhard Karls University of Tuebingen, 72076 Tuebingen, Germany.

Funding

Brain and Behavior Research Foundation 23494Deutsche Forschungsgemeinschaft DFG NI 1332/6-1Ministry of Science, Research and Arts, Baden-Württemberg not available
6 · The paper itself

Abstract

Early-life adversity (ELA) is characterized by exposure to traumatic events during early periods of life, particularly involving emotional, sexual and/or physical adversities during childhood. Mental disorders are strongly influenced by environmental and lifestyle-related risk factors including ELA. However, the molecular link between ELA and the risk of an adult mental disorder is still not fully understood. Evidence is emerging that long-lasting changes in the epigenetic processes regulating gene expression, such as DNA methylation, play an important role in the biological mechanisms linking ELA and mental disorders. Based on a recent study, we analyzed the DNA methylation of a specific CpG site within the gene

Indexed as

DNA MethylationAdultAdverse Childhood ExperiencesBorderline Personality DisorderCpG IslandsEpigenesis, GeneticFemaleHumansMajor Depressive DisorderMaleMental DisordersMiddle AgedPeroxidasinPeroxidasinPXDN protein, humanBorderline Personality Disorder (BPD)DNA methylationEarly-life Adversity (ELA)Major Depressive Disorder (MDD)Mental DisordersPXDNSocial Anxiety Disorder (SAD)

Identifiers

PMID39199364
PMCPMC11353138

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.