Evidence map›Paper›PMID 39199304›Full record

ReviewBiomolecules2024

Epigenetic Modifiers in Cancer Metastasis.

Die Hu, Tianci Zhao, Chenxing Xu, Xinyi Pan, Zhengyu Zhou, Shengjie Wang

Abstract readReview
In one paragraph

Review in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Die HuKey Laboratory of Molecular Genetics between Kangda College of Nanjing Medical University and Suzhou Medical College of Soochow University, Suzhou 215123, China.
Tianci ZhaoKey Laboratory of Cell Biology, Ministry of Public Health and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang 110122, China.
Chenxing XuDepartment of Basic Medicine, Kangda College of Nanjing Medical University, Lianyungang 222000, China.
Xinyi PanDepartment of Basic Medicine, Kangda College of Nanjing Medical University, Lianyungang 222000, China.
Zhengyu ZhouKey Laboratory of Molecular Genetics between Kangda College of Nanjing Medical University and Suzhou Medical College of Soochow University, Suzhou 215123, China.
Shengjie WangKey Laboratory of Molecular Genetics between Kangda College of Nanjing Medical University and Suzhou Medical College of Soochow University, Suzhou 215123, China.ORCID 0000-0003-0320-0377

Funding

2023 Research Project of Jiangsu Laboratory Animal Association DWXH202306Lianyungang Key R&D Program (Social Development) SF2207National Natural Science Foundation of China 82203773Natural Science Foundation of Jiangsu Province BK20231233Scientific Research and Development Foundation of Kangda College of Nanjing Medical University KD2023KYJJ009Scientific Research and Development foundation of Nanjing Medical University NMUB20230270
6 · The paper itself

Abstract

Metastasis is the primary cause of cancer-related death, with the dissemination and colonization of primary tumor cells at the metastatic site facilitated by various molecules and complex pathways. Understanding the biological mechanisms underlying the metastatic process is critical for the development of effective interventions. Several epigenetic modifications have been identified that play critical roles in regulating cancer metastasis. This review aims to provide a comprehensive summary of recent advances in understanding the role of epigenetic modifiers, including histone modifications, DNA methylation, non-coding RNAs, enhancer reprogramming, chromatin accessibility, and N6-methyladenosine, in metastasis-associated processes, such as epithelial-mesenchymal transition (EMT), cancer cell migration, and invasion. In particular, this review provides a detailed and in-depth description of the role of crosstalk between epigenetic regulators in tumor metastasis. Additionally, we explored the potential and limitations of epigenetics-related target molecules in the diagnosis, treatment, and prognosis of cancer metastasis.

Indexed as

DNA MethylationEpigenesis, GeneticEpithelial-Mesenchymal TransitionNeoplasm MetastasisNeoplasmsAdenosineAnimalsGene Expression Regulation, NeoplasticHistonesHumansAdenosineHistonesDNA methylationepigeneticshistone methylationmetastasisnon-coding RNAs

Identifiers

PMID39199304
PMCPMC11352731

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.