Evidence map›Paper›PMID 39199297›Full record

ArticleBiomolecules2024

Markers of Mitochondrial Function and DNA Repair Associated with Physical Function in Centenarians.

Ines Sanchez-Roman, Beatriz Ferrando, Camilla Myrup Holst, Jonas Mengel-From, Signe Hoei Rasmussen, Mikael Thinggaard, Vilhelm A Bohr, Kaare Christensen, Tinna Stevnsner

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ines Sanchez-RomanDepartment of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus, Denmark.ORCID 0000-0003-4844-5781
Beatriz FerrandoDepartment of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus, Denmark.
Camilla Myrup HolstDepartment of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus, Denmark.
Jonas Mengel-FromDanish Aging Research Center, Department of Public Health, University of Southern Denmark, 5230 Odense, Denmark.ORCID 0000-0003-1573-8908
Signe Hoei RasmussenDanish Aging Research Center, Department of Public Health, University of Southern Denmark, 5230 Odense, Denmark.
Mikael ThinggaardDanish Aging Research Center, Department of Public Health, University of Southern Denmark, 5230 Odense, Denmark.ORCID 0000-0002-7029-453X
Vilhelm A BohrDepartment of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen, Denmark.
Kaare ChristensenDanish Aging Research Center, Department of Public Health, University of Southern Denmark, 5230 Odense, Denmark.ORCID 0000-0002-5429-5292
Tinna StevnsnerDepartment of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus, Denmark.

Funding

Novo Nordisk Fundation, Health Fundation, Danish interdisciplinary Research Council, Intramural Program of the National Institute on Aging, Velux Foundation Grant nr.16-B-0271
6 · The paper itself

Abstract

Mitochondrial dysfunction and genomic instability are key hallmarks of aging. The aim of this study was to evaluate whether maintenance of physical capacities at very old age is associated with key hallmarks of aging. To investigate this, we measured mitochondrial bioenergetics, mitochondrial DNA (mtDNA) copy number and DNA repair capacity in peripheral blood mononuclear cells from centenarians. In addition, circulating levels of NAD+/NADH, brain-derived neurotrophic factor (BDNF) and carbonylated proteins were measured in plasma and these parameters were correlated to physical capacities. Centenarians without physical disabilities had lower mitochondrial respiration values including ATP production, reserve capacity, maximal respiration and non-mitochondrial oxygen-consumption rate and had higher mtDNA copy number than centenarians with moderate and severe disabilities (

Indexed as

Brain-Derived Neurotrophic FactorDNA, MitochondrialDNA RepairMitochondriaAged, 80 and overAgingBiomarkersDNA-(Apurinic or Apyrimidinic Site) LyaseDNA Copy Number VariationsEnergy MetabolismFemaleHand StrengthHumansLeukocytes, MononuclearMaleNADAPEX1 protein, humanBDNF protein, humanBiomarkersBrain-Derived Neurotrophic FactorDNA-(Apurinic or Apyrimidinic Site) LyaseDNA, MitochondrialNADcentenariansDNA repairgrip strengthmitochondriaphysical function

Identifiers

PMID39199297
PMCPMC11353237

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.