Evidence map›Paper›PMID 39199295›Full record

ArticleBiomolecules2024

Decellularized Antler Cancellous Bone Matrix Material Can Serve as Potential Bone Tissue Scaffold.

Yusu Wang, Ying Zong, Weijia Chen, Naichao Diao, Quanmin Zhao, Chunyi Li, Boyin Jia, Miao Zhang, Jianming Li, Yan Zhao and 2 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Yusu WangCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Ying ZongCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.ORCID 0000-0003-0730-0519
Weijia ChenCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Naichao DiaoCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Quanmin ZhaoCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Chunyi LiCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Boyin JiaCollege of Animal Medicine, College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, China.
Miao ZhangCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Jianming LiCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Yan ZhaoCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Rui DuCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Zhongmei HeCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.

Funding

Rui Du 20220304001YYZhongmei He 20220304002YYZhongmei He 202300801-04Zhongmei He 23JQ08
6 · The paper itself

Abstract

Due to the limited supply of autologous bone grafts, there is a need to develop more bone matrix materials to repair bone defects. Xenograft bone is expected to be used for clinical treatment due to its exact structural similarity to natural bone and its high biocompatibility. In this study, decellularized antler cancellous bone matrix (DACB) was first prepared, and then the extent of decellularization of DACB was verified by histological staining, which demonstrated that it retained the extracellular matrix (ECM). The bioactivity of DACB was assessed using C3H10T1/2 cells, revealing that DACB enhanced cell proliferation and facilitated cell adhesion and osteogenic differentiation. When evaluated by implanting DACB into nude mice, there were no signs of necrosis or inflammation in the epidermal tissues. The bone repair effect of DACB was verified in vivo using sika deer during the antler growth period as an animal model, and the molecular mechanisms of bone repair were further evaluated by transcriptomic analysis of the regenerated tissues. Our findings suggest that the low immunogenicity of DACB enhances the production of bone extracellular matrix components, leading to effective osseointegration between bone and DACB. This study provides a new reference for solving bone defects.

Indexed as

AntlersCancellous BoneDeerMice, NudeOsteogenesisTissue ScaffoldsAnimalsBone RegenerationCell AdhesionCell DifferentiationCell LineCell ProliferationDecellularized Extracellular MatrixExtracellular MatrixMiceTissue EngineeringDecellularized Extracellular Matrixantlerbiomaterialsbone repairdecellularized cancellous bone matrixRNA-sequencing analysis

Identifiers

PMID39199295
PMCPMC11353137

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.