Evidence map›Paper›PMID 39199290›Full record

ArticleBiomolecules2024

Increased Odds of Metabolic Dysfunction-Associated Steatotic Liver Disease Are Linked to Reduced n-6, but Not n-3 Polyunsaturated Fatty Acids in Plasma.

Irena Frankovic, Ivana Djuricic, Ana Ninic, Jelena Vekic, Tara Vorkapic, Sanja Erceg, Tamara Gojkovic, Ratko Tomasevic, Milica Mamic, Milos Mitrovic and 1 more

Abstract read
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Irena FrankovicDepartment of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, Serbia.
Ivana DjuricicDepartment of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0002-0539-4585
Ana NinicDepartment of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0003-3838-1606
Jelena VekicDepartment of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, Serbia.
Tara VorkapicDepartment of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, Serbia.
Sanja ErcegDepartment of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0002-7229-9406
Tamara GojkovicDepartment of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, Serbia.
Ratko TomasevicFaculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Milica MamicDepartment of Laboratory Diagnostics, Clinical Hospital Center Zemun, 11080 Belgrade, Serbia.
Milos MitrovicClinical Department for Gastroenterology and Hepatology, University Medical Center Zvezdara, 11000 Belgrade, Serbia.ORCID 0000-0003-4150-3707
Aleksandra ZeljkovicDepartment of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0001-6417-8404

Funding

Ministry of Science, Technological Development and Innovation, Republic of Serbia 451-03-65/2024-03/ 200161 and 451-03-66/2024-03/ 200161
6 · The paper itself

Abstract

The increasing prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) underscores the need for better understanding of its complex pathogenesis. Lipid accumulation in hepatocytes is among principal mechanisms contributing to MASLD development. While routine lipid parameters are well studied, the profile of circulating fatty acids in MASLD patients remains less explored. This study aimed to assess relative proportions of individual fatty acids in plasma of MASLD patients and to explore their associations with other biochemical markers of MASLD. Ninety-one patients and 48 healthy individuals were enrolled. The relative proportions of fatty acids in plasma were determined using gas chromatography with FID detection. Proportions of total n-6 polyunsaturated fatty acids (PUFAs) and linoleic acid (LA) in plasma were lower in MASLD patients (

Indexed as

Fatty Acids, Omega-3Fatty Acids, Omega-6AdultAgedBiomarkersBody Mass IndexCase-Control StudiesFatty LiverFemaleHumansMaleMiddle AgedBiomarkersFatty Acids, Omega-3Fatty Acids, Omega-6linoleic acidMASLDn-3 PUFAsn-6 PUFAsplasma fatty acids

Identifiers

PMID39199290
PMCPMC11353166

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.