Evidence map›Paper›PMID 39199273›Full record

ArticleBiomolecules2024

Impact of Serotonin Transporter Absence on Brain Insulin Receptor Expression, Plasma Metabolome Changes, and ADHD-like Behavior in Mice fed a Western Diet.

Daniel C Anthony, Fay Probert, Anna Gorlova, Jenna Hebert, Daniel Radford-Smith, Zlata Nefedova, Aleksei Umriukhin, Andrey Nedorubov, Raymond Cespuglio, Boris Shulgin and 3 more

Abstract read
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Daniel C AnthonyDepartment of Pharmacology, Oxford University, Oxford OX1 3QT, UK.ORCID 0000-0003-1380-6655
Fay ProbertDepartment of Pharmacology, Oxford University, Oxford OX1 3QT, UK.
Anna GorlovaResearch and Education Resource Center, Peoples Friendship University of Russia (RUDN University), 117198 Moscow, Russia.
Jenna HebertDepartment of Pharmacology, Oxford University, Oxford OX1 3QT, UK.
Daniel Radford-SmithDepartment of Pharmacology, Oxford University, Oxford OX1 3QT, UK.ORCID 0000-0001-8781-7459
Zlata NefedovaDepartment of Normal Physiology, Sechenov First Moscow State Medical University, 119991 Moscow, Russia.
Aleksei UmriukhinDepartment of Normal Physiology, Sechenov First Moscow State Medical University, 119991 Moscow, Russia.
Andrey NedorubovDepartment of Normal Physiology, Sechenov First Moscow State Medical University, 119991 Moscow, Russia.ORCID 0000-0002-5915-7999
Raymond CespuglioResearch and Education Resource Center, Peoples Friendship University of Russia (RUDN University), 117198 Moscow, Russia.ORCID 0000-0003-2246-8643
Boris ShulginLaboratory of Engineering Profile Physical and Chemical Methods of Analysis, Korkyt Ata Kyzylorda University, Kyzylorda 120014, Kazakhstan.
Aleksey LyundupResearch and Education Resource Center, Peoples Friendship University of Russia (RUDN University), 117198 Moscow, Russia.
Klaus Peter LeschDivision of Molecular Psychiatry, Center of Mental Health, University Hospital Würzburg, 97080 Würzburg, Germany.
Tatyana StrekalovaDepartment of Pharmacology, Oxford University, Oxford OX1 3QT, UK.

Funding

EU Framework research and innovation programme, Marie Skłodowvska-Curie Aqua-SynapseMinistry of Research and Higher Education RF 075-15-2022-310University of Würzburg, Germany UKRI EP/Y000420/1
6 · The paper itself

Abstract

The impaired function of the serotonin transporter (SERT) in humans has been linked to a higher risk of obesity and type 2 diabetes, especially as people age. Consuming a "Western diet" (WD), which is high in saturated fats, cholesterol, and sugars, can induce metabolic syndrome. Previous research indicated that mice carrying a targeted inactivation of the

Indexed as

Attention Deficit Disorder with HyperactivityBrainDiet, WesternMetabolomeMice, KnockoutReceptor, InsulinSerotonin Plasma Membrane Transport ProteinsAnimalsBehavior, AnimalMaleMiceMice, Inbred C57BLInsr protein, mouseReceptor, InsulinSerotonin Plasma Membrane Transport ProteinsSlc6a4 protein, mouseADHDagingglucose toleranceinsulin receptorsmetabolomicsserotonin transporterSert-deficient micewestern diet

Identifiers

PMID39199273
PMCPMC11351952

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.