Evidence map›Paper›PMID 39199243›Full record

ArticleAntioxidants (Basel, Switzerland)2024

Oxidative Stress in Transthyretin-Mediated Amyloidosis: An Exploratory Study.

Marco Fiore, Chiara Cambieri, Laura Libonati, Federica Moret, Edoardo D'Andrea, Maria Grazia Di Certo, Claudio Passananti, Francesca Gabanella, Nicoletta Corbi, Matteo Garibaldi and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Cardiovascular Aging.Reviews in cardiovascular medicine · 2025
    Review
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Marco FioreCNR-Institute of Biochemistry and Cell Biology, Via Ercole Ramarini 32, 00015 Monterotondo, Italy.ORCID 0000-0001-6806-9715
Chiara CambieriCenter for Rare Neuromuscular Diseases, Department of Human Neuroscience, Sapienza University of Rome, Viale dell'Università 30, 00185 Rome, Italy.ORCID 0000-0001-9424-7730
Laura LibonatiCenter for Rare Neuromuscular Diseases, Department of Human Neuroscience, Sapienza University of Rome, Viale dell'Università 30, 00185 Rome, Italy.ORCID 0000-0002-4323-3598
Federica MoretCenter for Rare Neuromuscular Diseases, Department of Human Neuroscience, Sapienza University of Rome, Viale dell'Università 30, 00185 Rome, Italy.
Edoardo D'AndreaCenter for Rare Neuromuscular Diseases, Department of Human Neuroscience, Sapienza University of Rome, Viale dell'Università 30, 00185 Rome, Italy.
Maria Grazia Di CertoCNR-Institute of Biochemistry and Cell Biology, Via Ercole Ramarini 32, 00015 Monterotondo, Italy.ORCID 0000-0003-1864-2274
Claudio PassanantiCNR-Institute of Molecular Biology and Pathology, Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 291, 00161 Rome, Italy.ORCID 0000-0002-9288-5736
Francesca GabanellaCNR-Institute of Biochemistry and Cell Biology, Via Ercole Ramarini 32, 00015 Monterotondo, Italy.
Nicoletta CorbiCNR-Institute of Molecular Biology and Pathology, Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 291, 00161 Rome, Italy.ORCID 0000-0002-4505-1632
Matteo GaribaldiDepartment of Neuroscience, Mental Health, and Sensory Organs (NESMOS), Sant'Andrea Hospital, Sapienza University, 00189 Rome, Italy.ORCID 0000-0003-1830-2886
Cristina ChimentiDepartment of Clinical, Internal, Anesthesiologist and Cardiovascular Sciences, Sapienza University of Rome, 00185 Rome, Italy.
Maria AlfaranoDepartment of Clinical, Internal, Anesthesiologist and Cardiovascular Sciences, Sapienza University of Rome, 00185 Rome, Italy.
Giampiero FerragutiDepartment of Experimental Medicine, Sapienza University of Rome, 00185 Roma, Italy.ORCID 0000-0001-6129-4071
Silvia FrancatiDepartment of Experimental Medicine, Sapienza University of Rome, 00185 Roma, Italy.ORCID 0009-0009-7672-6696
Maurizio InghilleriCenter for Rare Neuromuscular Diseases, Department of Human Neuroscience, Sapienza University of Rome, Viale dell'Università 30, 00185 Rome, Italy.ORCID 0000-0001-5365-3417
Marco CeccantiCenter for Rare Neuromuscular Diseases, Department of Human Neuroscience, Sapienza University of Rome, Viale dell'Università 30, 00185 Rome, Italy.ORCID 0000-0001-8897-3736

Funding

This research was funded by Sapienza University of Rome through a research grant (ref. RM12218163F49C9E 2022). RM12218163F49C9E 2022
6 · The paper itself

Abstract

Transthyretin-mediated amyloidosis (ATTR) is a systemic disease with protein precipitation in many tissues, mainly the peripheral nerve and heart. Both genetic (ATTRv, "v" for variant) and wild-type (ATTRwt) forms are known. Beyond the steric encumbrance, precipitated transthyretin seems to have a toxic effect. In this study carried out in men, we recruited 15 ATTRv patients, 7 ATTRv asymptomatic carriers, 14 ATTRwt patients and 10 young and 13 old healthy controls to evaluate the oxidative stress using FORD (Free Oxygen Radicals Defense) and FORT (Free Oxygen Radicals Test) analyses. ATTRv patients showed reduced FORD compared to ATTRwt and ATTRv asymptomatic carriers. FORD independently predicted the disease stage, with the early stages characterized by the highest consumption. These findings suggest a role for oxidative stress in the early stages of ATTRv.

Indexed as

amyloidosisFORDFORToxidative stresstransthyretin

Identifiers

PMID39199243
PMCPMC11351233

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.