Evidence map›Paper›PMID 39199240›Full record

ArticleAntioxidants (Basel, Switzerland)2024

A Randomised, Double-Blind, Placebo-Controlled, Cross-Over Clinical Trial to Evaluate the Biological Effects and Safety of a Polyphenol Supplement on Healthy Ageing.

Joyce Ruifen Chong, Chiara de Lucia, Diego Alejandro Tovar-Rios, Nicolas Castellanos-Perilla, Christopher Collins, Silje Meihack Kvernberg, Clive Ballard, Richard C Siow, Dag Aarsland

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Joyce Ruifen ChongCentre for Healthy Brain Ageing, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London S5 9NU, UK.
Chiara de LuciaCentre for Healthy Brain Ageing, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London S5 9NU, UK.ORCID 0000-0002-7541-2814
Diego Alejandro Tovar-RiosCentre for Age-Related Medicine, Stavanger University Hospital, 4019 Stavanger, Norway.
Nicolas Castellanos-PerillaCentre for Age-Related Medicine, Stavanger University Hospital, 4019 Stavanger, Norway.ORCID 0000-0002-8229-2611
Christopher CollinsMuhdo Health Ltd., Columba House, Adastral Park, Martlesham Heath, Martlesham, Ipswich IP5 3RE, UK.ORCID 0000-0003-2850-1950
Silje Meihack KvernbergCentre for Age-Related Medicine, Stavanger University Hospital, 4019 Stavanger, Norway.
Clive BallardUniversity of Exeter Medical School, University of Exeter, Exeter EX1 2HZ, UK.
Richard C SiowSchool of Cardiovascular and Metabolic Medicine & Sciences, British Heart Foundation Centre of Research Excellence, Faculty of Life Sciences & Medicine, King's College London, London SE1 9NH, UK.ORCID 0000-0003-4603-9763
Dag AarslandCentre for Healthy Brain Ageing, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London S5 9NU, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DailyColors™ is a supplement made up of several phytonutrients that aims to replicate elements from the Mediterranean diet. These include fruit, berry and vegetable extracts that are rich in key phytochemicals such as Quercetin, Catechins, Phloretin, Ellagic Acid, and Anthocyanins. Here, we determined the effects of DailyColors™ on the blood biomarkers associated with the diverse mechanisms implicated in ageing and age-related diseases, including mitochondrial function, inflammation, and oxidative stress, as well as on saliva's DNA methylation pattern. Thirty adult participants (mean (SD) age = 67.0 (7.5) years) with a body mass index over 25 were recruited into this randomised, double-blind, placebo-controlled, cross-over trial (two one-week treatment periods, separated by a one-week washout period). During the placebo period, we observed a significant increase in blood CD38 concentrations from the baseline to 24 h (

Indexed as

DNA methylationinflammationMediterranean dietmitochondrial dysfunctionoxidative stress

Identifiers

PMID39199240
PMCPMC11352085

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.