Evidence map›Paper›PMID 39199229›Full record

ArticleAntioxidants (Basel, Switzerland)2024

Curcumin Supplementation and Vascular and Cognitive Function in Chronic Kidney Disease: A Randomized Controlled Trial.

Colin J Gimblet, Nicholas T Kruse, Katharine Geasland, Jeni Michelson, Mingyao Sun, Patrick Ten Eyck, Cari Linkenmeyer, Safur Rehman Mandukhail, Matthew J Rossman, Meenakshi Sambharia and 5 more

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Colin J GimbletDivision of Nephrology, Department of Internal Medicine, Carver College of Medicine, University of Iowa, 375 Newton Rd, Iowa City, IA 52246, USA.ORCID 0000-0002-3024-2284
Nicholas T KruseCollege of Health Professionals, Central Michigan University, Mount Pleasant, MI 48859, USA.
Katharine GeaslandInstitute for Clinical and Translational Science, University of Iowa, Iowa City, IA 52246, USA.
Jeni MichelsonInstitute for Clinical and Translational Science, University of Iowa, Iowa City, IA 52246, USA.
Mingyao SunDivision of Nephrology, Department of Internal Medicine, Carver College of Medicine, University of Iowa, 375 Newton Rd, Iowa City, IA 52246, USA.
Patrick Ten EyckInstitute for Clinical and Translational Science, University of Iowa, Iowa City, IA 52246, USA.
Cari LinkenmeyerDepartment of Psychiatry, University of Iowa, Iowa City, IA 52246, USA.
Safur Rehman MandukhailDivision of Nephrology, Department of Internal Medicine, Carver College of Medicine, University of Iowa, 375 Newton Rd, Iowa City, IA 52246, USA.
Matthew J RossmanDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO 80309, USA.ORCID 0000-0001-9381-2590
Meenakshi SambhariaDivision of Nephrology, Department of Internal Medicine, Carver College of Medicine, University of Iowa, 375 Newton Rd, Iowa City, IA 52246, USA.
Michel ChoncholDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Manjula Kurella TamuraDivision of Nephrology, Department of Medicine, Stanford University School of Medicine, Palo Alto, CA 94305, USA.ORCID 0000-0001-5227-2479
Douglas SealsDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO 80309, USA.
Karin F HothDepartment of Psychiatry, University of Iowa, Iowa City, IA 52246, USA.
Diana JalalDivision of Nephrology, Department of Internal Medicine, Carver College of Medicine, University of Iowa, 375 Newton Rd, Iowa City, IA 52246, USA.ORCID 0000-0002-1975-8650

Funding

University of Iowa Institute for Clinical and Translational ScienceUM1TR004403 · NCATS · UNIVERSITY OF IOWA · PI Marlan R Hansen, Patricia Winokur · 2023 to 2026
$16.1M
Diabetes Research Training Program Diversity SupplementT32DK112751 · NIDDK · UNIVERSITY OF IOWA · PI Andrew W Norris · 2017 to 2026
$4.8M
Curcumin Supplementation for Improving Vascular and Cognitive FunctionR01HL134738 · NHLBI · UNIVERSITY OF IOWA · PI JALAL, DIANA I · 2017 to 2020
$2.3M
NCATS NIH HHS UM1 TR004403NHLBI NIH HHS R01 HL134738NIDDK NIH HHS T32 DK112751NIH HHS 1R01HL134738-23A1
6 · The paper itself

Abstract

Chronic kidney disease (CKD) increases the risk of cardiovascular disease and cognitive impairment. Curcumin is a polyphenol that improves vascular and cognitive function in older adults; however, its effects on vascular and cognitive function in patients with CKD are unknown. We hypothesized that curcumin supplementation would improve vascular and cognitive function in patients with CKD. Eighty-eight adults diagnosed with stage 3b or 4 CKD (aged 66 ± 8 years, 75% male) participated in a 12-month, randomized, double-blind, placebo-controlled study to test the effects of curcumin (Longvida

Indexed as

CKDcurcuminoxidative stressvascular function

Identifiers

PMID39199229
PMCPMC11352164

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.