Evidence map›Paper›PMID 39198853›Full record

ArticleJournal of orthopaedic surgery and research2024

Novel insights into vancomycin-loaded calcium sulfate and negative pressure wound therapy in preventing infections in open fractures.

Bei Jia, Rui Xue, Jia Li, Jichao Guo, Jianning Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedic surgery and research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Bei JiaNosocomial Infection Management Department, Hebei Medical University First Hospital, No. 89 Donggang Road, Yuhua District, Shijiazhuang City, China.
Rui XueDepartment of Orthopaedic Suigery, Hebei Medical University Third Hospital, No. 139 ZiQiang Road, QiaoXi District, Shijiazhuang City, Hebei Province, China.
Jia LiDepartment of Orthopaedic Suigery, Hebei Medical University Third Hospital, No. 139 ZiQiang Road, QiaoXi District, Shijiazhuang City, Hebei Province, China.
Jichao GuoDepartment of Orthopaedic Suigery, Hebei Medical University Third Hospital, No. 139 ZiQiang Road, QiaoXi District, Shijiazhuang City, Hebei Province, China.
Jianning LiuDepartment of Orthopaedic Suigery, Hebei Medical University Third Hospital, No. 139 ZiQiang Road, QiaoXi District, Shijiazhuang City, Hebei Province, China. 37900477@hebmu.edu.cn.

Funding

National Outstanding Youth Science Fund Project of National Natural Science Foundation of China No. 51771069
6 · The paper itself

Abstract

backgroundOpen fractures are challenging due to susceptibility to Staphylococcus aureus infections. This study examines the impact of Vancomycin-Loaded Calcium Sulfate (VLCS) and negative pressure wound therapy (NPWT) on macrophage behavior in enhancing healing and infection resistance. Both VLCS and NPWT were evaluated individually and in combination to determine their effects on macrophage polarization and infection resistance in open fractures.

methodsThrough single-cell RNA sequencing, genomic expressions in macrophages from open fracture patients treated with VLCS and NPWT were compared to a control group. The analysis focused on MBD2 gene changes related to macrophage polarization.

resultsRemarkable modifications in MBD2 expression in the treatment group indicate a shift towards M2 macrophage polarization. Additionally, the combined treatment group exhibited greater improvements in infection resistance and healing compared to the individual treatments. This shift suggests a healing-promoting atmosphere with improved infection resilience.

conclusionsVLCS and NPWT demonstrate the ability to alter macrophage behavior toward M2 polarization, which is crucial for infection prevention in open fractures. The synergistic effect of their combined use shows even greater promise in enhancing outcomes in orthopedic trauma care.

Indexed as

Calcium SulfateFractures, OpenMacrophagesNegative-Pressure Wound TherapyVancomycinAdultAnti-Bacterial AgentsFemaleHumansMaleMiddle AgedStaphylococcal InfectionsSurgical Wound InfectionWound HealingAnti-Bacterial AgentsCalcium SulfateVancomycinM2Macrophage polarizationNegative pressure wound therapyOpen fracturesStaphylococcus aureus infectionsVancomycin-Loaded Calcium Sulfate

Identifiers

PMID39198853
PMCPMC11360527

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.