Evidence map›Paper›PMID 39198735›Full record

ArticleBMC cardiovascular disorders2024

The soluble ST2 level predicts risk of atrial fibrillation recurrences in long-term period after radiofrequency ablation.

Tatiana P Gizatulina, Aleksandra V Mamarina, Leysan U Martyanova, Denis V Belonogov, Grigoriy V Kolunin, Tatiana I Petelina, Nikita E Shirokov, Elena A Gorbatenko

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Predictors of atrial fibrillation recurrence after catheter ablation: a systematic review.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tatiana P GizatulinaTyumen Cardiology Research Center, Tomsk National Research Medical Center of the Russian Academy of Sciences, 111 Melnikaite Street, Tyumen, 625026, Russian Federation. gizatulinatp@infarkta.net.
Aleksandra V MamarinaTyumen Cardiology Research Center, Tomsk National Research Medical Center of the Russian Academy of Sciences, 111 Melnikaite Street, Tyumen, 625026, Russian Federation.
Leysan U MartyanovaTyumen Cardiology Research Center, Tomsk National Research Medical Center of the Russian Academy of Sciences, 111 Melnikaite Street, Tyumen, 625026, Russian Federation.
Denis V BelonogovTyumen Cardiology Research Center, Tomsk National Research Medical Center of the Russian Academy of Sciences, 111 Melnikaite Street, Tyumen, 625026, Russian Federation.
Grigoriy V KoluninTyumen Cardiology Research Center, Tomsk National Research Medical Center of the Russian Academy of Sciences, 111 Melnikaite Street, Tyumen, 625026, Russian Federation.
Tatiana I PetelinaTyumen Cardiology Research Center, Tomsk National Research Medical Center of the Russian Academy of Sciences, 111 Melnikaite Street, Tyumen, 625026, Russian Federation.
Nikita E ShirokovTyumen Cardiology Research Center, Tomsk National Research Medical Center of the Russian Academy of Sciences, 111 Melnikaite Street, Tyumen, 625026, Russian Federation.
Elena A GorbatenkoTyumen Cardiology Research Center, Tomsk National Research Medical Center of the Russian Academy of Sciences, 111 Melnikaite Street, Tyumen, 625026, Russian Federation.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesThe hypothesis of the study was the assumption that the serum levels of soluble ST2 (sST2) and growth differentiation factor (GDF-15) can be predictors of atrial fibrillation (AF) recurrence in long-term period after primary radiofrequency catheter ablation (RFA).

methodsOf the 165 patients included in the prospective follow-up, the final analysis included 131 patients whose follow-up duration reached 18 months after the end of the blanking period (3 months after RFA). The median age of patients was 59.0 (50.0; 64.0) years, and 80 (61%) were men. Paroxysmal AF was present in 103 (79%) and persistent AF in 28 (21%) patients. All patients underwent transthoracic and transesophageal echocardiography, and electroanatomic mapping was used to assess the area of low-voltage zones (LVZ). sST2 and GDF-15 levels were determined by ELISA using GDF-15/MIC-1 analytical kits (BioVender, Czech Republic) and Presage ST2 (Critical Diagnostics, USA) before RFA. After RFA, patients had regular follow-up visits at 3-6-9-12-18 months with 12-lead ECG or Holter ECG monitoring and with clinical evaluation. The primary endpoint was the occurrence of the first symptomatic AF recurrence (AFr) lasting > 30 s, recorded on an ECG or during daily ECG monitoring, after a blanking period.

resultsAt the 18-month follow-up, 47 patients (35.9%) had AFr. The groups with and without AFr didn`t differ in the LVZ area. The medians of NT-proBNP, GDF-15 and sST2 also didn`t differ significantly between the groups, but in patients with AFr, the proportion of those with sST2 ≥ 36 ng/ml (the border of the lower and middle terziles) was higher (p = 0.03). According to the one-factor Cox regression analysis, AFr were associated with four factors: AF history ≥ 1 year, early AFr (during the blanking period), left atrial appendage flow velocity (LAAFV) < 54 cm/sec and sST2 ≥ 36 ng/ml. In the multivariate Cox analysis two independent predictors of AFr were obtained: sST2 ≥ 36 ng/ml (HR = 3.8; 95% CI 1.5-9.8, p = 0.006) and LAAFV < 54 сm/sec (HR = 1.96; 95% CI 1.01-3.82, p = 0.048).

conclusionsSerum sST2 level with a cut-off value of 36 ng/ml or more can be used as a predictor of AF recurrence in the long-term period after primary RFA.

Indexed as

Atrial FibrillationBiomarkersCatheter AblationGrowth Differentiation Factor 15Interleukin-1 Receptor-Like 1 ProteinPredictive Value of TestsRecurrenceAgedElectrocardiography, AmbulatoryFemaleHumansMaleMiddle AgedProspective StudiesRisk AssessmentRisk FactorsBiomarkersGDF15 protein, humanGrowth Differentiation Factor 15IL1RL1 protein, humanInterleukin-1 Receptor-Like 1 ProteinAtrial fibrillationBiomarkersLeft atrial fibrosisRadiofrequency ablationsST2

Identifiers

PMID39198735
PMCPMC11350941

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.