Evidence map›Paper›PMID 39198717›Full record

ArticleFEBS letters2024

Structural modeling and characterization of the Mycobacterium tuberculosis MmpL3 C-terminal domain.

Naomi Berkowitz, Allison MacMillan, Marit B Simmons, Ujwal Shinde, Georgiana E Purdy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Naomi BerkowitzDepartment of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, OR, USA.
Allison MacMillanDepartment of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, OR, USA.
Marit B SimmonsDepartment of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, OR, USA.
Ujwal ShindeBiophysics Core Facility, Oregon Health & Science University, Portland, OR, USA.
Georgiana E PurdyDepartment of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, OR, USA.ORCID https://orcid.org/0000-0002-0739-6867

Funding

The MmpL3 interactomeR21AI167112 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI PURDY, GEORGIANA E. · 2021 to 2022
$438k
National Institute of Allergy and Infectious Diseases R21AI167112NIAID NIH HHS R21 AI167112
6 · The paper itself

Abstract

The Mycobacterium tuberculosis (Mtb) cell envelope provides a protective barrier against the immune response and antibiotics. The mycobacterial membrane protein large (MmpL) family of proteins export cell envelope lipids and siderophores; therefore, these proteins are important for the basic biology and pathogenicity of Mtb. In particular, MmpL3 is essential and a known drug target. Despite interest in MmpL3, the structural data in the field are incomplete. Utilizing homology modeling, AlphaFold, and biophysical techniques, we characterized the cytoplasmic C-terminal domain (CTD) of MmpL3 to better understand its structure and function. Our in silico models of the MmpL11

Indexed as

Bacterial ProteinsModels, MolecularMycobacterium tuberculosisProtein DomainsAmino Acid SequenceMembrane Transport ProteinsBacterial ProteinsMembrane Transport ProteinsMmpL3 protein, Mycobacterium tuberculosisMmpL11MmpL3molecular modelingMycobacterium tuberculosistransporter

Identifiers

PMID39198717
PMCPMC11560685

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.