Evidence map›Paper›PMID 39198706›Full record

ArticleCommunications biology2024

Polymodal K

Rían W Manville, Ryan F Yoshimura, Andriy V Yeromin, Derk Hogenkamp, Jennifer van der Horst, Angel Zavala, Sonia Chinedu, Grey Arena, Emma Lasky, Mark Fisher and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Molecules (Basel, Switzerland) · 2025
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Rían W Manville *Bioelectricity Laboratory, Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA.
Ryan F Yoshimura *Bioelectricity Laboratory, Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA.
Andriy V YerominDepartment of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA.ORCID 0000-0002-2274-7805
Derk HogenkampBioelectricity Laboratory, Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA.
Jennifer van der HorstDepartment of Biomedical Sciences, Vascular Biology Group, Panum Institute, University of Copenhagen, Copenhagen, Denmark.
Angel ZavalaDepartment of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA.
Sonia ChineduBioelectricity Laboratory, Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA.
Grey ArenaRedwood Creek Vegetation Team, National Park Service, Sausalito, CA, USA.
Emma LaskyRedwood Creek Vegetation Team, National Park Service, Sausalito, CA, USA.
Mark FisherPhilip L. Boyd Deep Canyon Desert Research Center, University of California Natural Reserve System, Indian Wells, CA, USA.
Christopher R TracyPhilip L. Boyd Deep Canyon Desert Research Center, University of California Natural Reserve System, Indian Wells, CA, USA.ORCID 0000-0002-8283-8733
Shivashankar OthyDepartment of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA.
Thomas A JeppsDepartment of Biomedical Sciences, Vascular Biology Group, Panum Institute, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-9903-714X
Michael D CahalanDepartment of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA.
Geoffrey W AbbottBioelectricity Laboratory, Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA. abbottg@hs.uci.edu.ORCID 0000-0003-4552-496X

Funding

Ion Channel Transporter InteractionsR35GM130377 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Geoffrey W Abbott · 2019 to 2026
$4.0M
Tissue-Specific Mechanisms of Regulatory T Cells in the CNS during Autoimmune EncephalomyelitisR01AI168063 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI Shivashankar Othy · 2022 to 2026
$2.5M
Defining molecular mechanisms of combination adjuvants: a systems immunology, transcriptomics and imaging approachU01AI160397 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI DAVIES, DAVID HUW · 2021 to 2024
$2.4M
Lundbeckfonden (Lundbeck Foundation) R323-2018-3674NIAID NIH HHS R01 AI168063NIAID NIH HHS U01 AI160397NIGMS NIH HHS R35 GM130377U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI168063U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) U01AI160397U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) GM130377
6 · The paper itself

Abstract

Pain and inflammation contribute immeasurably to reduced quality of life, yet modern analgesic and anti-inflammatory therapeutics can cause dependence and side effects. Here, we screened 1444 plant extracts, prepared primarily from native species in California and the United States Virgin Islands, against two voltage-gated K

Indexed as

AnalgesicsAnti-Inflammatory AgentsPlant ExtractsAnimalsCoriandrumHumansMaleMiceMolecular Docking SimulationPlants, MedicinalPotassium Channel BlockersTanninsAnalgesicsAnti-Inflammatory AgentsPlant ExtractsPotassium Channel BlockersTannins

Identifiers

PMID39198706
PMCPMC11358443

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.