Evidence map›Paper›PMID 39198658›Full record

ArticleNature neuroscience2024

Activity of nested neural circuits drives different courtship songs in Drosophila.

Hiroshi M Shiozaki, Kaiyu Wang, Joshua L Lillvis, Min Xu, Barry J Dickson, David L Stern

Abstract read
In one paragraph

Article in Nature neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Uncovering Sex Differences in thebioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Review
  5. Sexual dimorphism in the complete connectome of thebioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. Article
  8. High-resolution comparative single-cell transcriptomics ofbioRxiv : the preprint server for biology · 2025
    Article
  9. Article
  10. Article
  11. Astrocyte antennae.Nature reviews. Neuroscience · 2024
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hiroshi M ShiozakiJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA. shiozaki.h@gmail.com.ORCID http://orcid.org/0000-0002-7175-0824
Kaiyu WangJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Joshua L LillvisJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID http://orcid.org/0000-0002-6235-8759
Min XuJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Barry J DicksonJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID http://orcid.org/0000-0003-0715-892X
David L SternJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA. sternd@janelia.hhmi.org.ORCID http://orcid.org/0000-0002-1847-6483

Funding

Wellcome Trust
6 · The paper itself

Abstract

Motor systems implement diverse motor programs to pattern behavioral sequences, yet how different motor actions are controlled on a moment-by-moment basis remains unclear. Here, we investigated the neural circuit mechanisms underlying the control of distinct courtship songs in Drosophila. Courting males rapidly alternate between two types of song: pulse and sine. By recording calcium signals in the ventral nerve cord in singing flies, we found that one neural population is active during both songs, whereas an expanded neural population, which includes neurons from the first population, is active during pulse song. Brain recordings showed that this nested activation pattern is present in two descending pathways required for singing. Connectomic analysis reveals that these two descending pathways provide structured input to ventral nerve cord neurons in a manner consistent with their activation patterns. These results suggest that nested premotor circuit activity, directed by distinct descending signals, enables rapid switching between motor actions.

Indexed as

CourtshipAnimalsBrainDrosophilaDrosophila melanogasterFemaleMaleNerve NetNeural PathwaysNeuronsSexual Behavior, AnimalVocalization, Animal

Identifiers

PMID39198658
PMCPMC11452343

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.