Evidence map›Paper›PMID 39198655›Full record

ArticleNature2024

Closed-loop transfer enables artificial intelligence to yield chemical knowledge.

Nicholas H Angello, David M Friday, Changhyun Hwang, Seungjoo Yi, Austin H Cheng, Tiara C Torres-Flores, Edward R Jira, Wesley Wang, Alán Aspuru-Guzik, Martin D Burke and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Machine Learning Accelerates Crystallization for Structure Determination.Angewandte Chemie (International ed. in English) · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Chemistry in Transformation: A European Moment.Angewandte Chemie (International ed. in English) · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Automated Iterative N─C and C─C Bond Formation.Angewandte Chemie (International ed. in English) · 2025
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Nicholas H Angello *Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID http://orcid.org/0000-0001-6436-3669
David M Friday *Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID http://orcid.org/0009-0004-3189-5115
Changhyun Hwang *Molecule Maker Lab, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID http://orcid.org/0000-0003-1720-7852
Seungjoo Yi *Molecule Maker Lab, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Austin H ChengDepartment of Chemistry, University of Toronto, Toronto, Ontario, Canada.
Tiara C Torres-FloresMolecule Maker Lab, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID http://orcid.org/0009-0003-9488-0765
Edward R JiraMolecule Maker Lab, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Wesley WangDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID http://orcid.org/0000-0002-1420-3031
Alán Aspuru-GuzikDepartment of Chemistry, University of Toronto, Toronto, Ontario, Canada. alan@aspuru.com.ORCID http://orcid.org/0000-0002-8277-4434
Martin D BurkeDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA. mdburke@illinois.edu.ORCID http://orcid.org/0000-0001-7963-7140
Charles M SchroederDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA. cms@illinois.edu.ORCID http://orcid.org/0000-0001-6023-2274
Ying DiaoDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA. yingdiao@illinois.edu.ORCID http://orcid.org/0000-0002-8984-0051
Nicholas E JacksonDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA. jacksonn@illinois.edu.ORCID http://orcid.org/0000-0002-1470-1903

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Artificial intelligence-guided closed-loop experimentation has emerged as a promising method for optimization of objective functions

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.