Evidence map›Paper›PMID 39198647›Full record

ArticleNature2024

Embryonic genome instability upon DNA replication timing program emergence.

Saori Takahashi, Hirohisa Kyogoku, Takuya Hayakawa, Hisashi Miura, Asami Oji, Yoshiko Kondo, Shin-Ichiro Takebayashi, Tomoya S Kitajima, Ichiro Hiratani

Abstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Trial
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  3. Review
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  11. Article
  12. Article
  13. Article
  14. Morphogen Gradients as Drivers of Mosaicism During Early Human Development.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  15. Article
  16. Nuclear Dynamics and Its Timing Regulation Revealed by Live-Cell Imaging.Advances in experimental medicine and biology · 2026
    Review
  17. How Early-Life Programming During Embryogenesis Imprints Cellular Memory.International journal of molecular sciences · 2025
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Saori Takahashi *Laboratory for Developmental Epigenetics, RIKEN Center for Biosystems Dynamics Research (BDR), Kobe, Japan.ORCID 0000-0001-9195-3656
Hirohisa Kyogoku *Laboratory for Chromosome Segregation, RIKEN Center for Biosystems Dynamics Research (BDR), Kobe, Japan. hirohisa.kyogoku@panda.kobe-u.ac.jp.ORCID 0000-0002-0364-3971
Takuya HayakawaLaboratory of Molecular & Cellular Biology, Graduate School of Bioresources, Mie University, Tsu, Japan.
Hisashi MiuraLaboratory for Developmental Epigenetics, RIKEN Center for Biosystems Dynamics Research (BDR), Kobe, Japan.
Asami OjiLaboratory for Developmental Epigenetics, RIKEN Center for Biosystems Dynamics Research (BDR), Kobe, Japan.ORCID 0000-0002-4919-0875
Yoshiko KondoLaboratory for Developmental Epigenetics, RIKEN Center for Biosystems Dynamics Research (BDR), Kobe, Japan.
Shin-Ichiro TakebayashiLaboratory of Molecular & Cellular Biology, Graduate School of Bioresources, Mie University, Tsu, Japan.
Tomoya S KitajimaLaboratory for Chromosome Segregation, RIKEN Center for Biosystems Dynamics Research (BDR), Kobe, Japan. tomoya.kitajima@riken.jp.ORCID 0000-0002-6486-7143
Ichiro HirataniLaboratory for Developmental Epigenetics, RIKEN Center for Biosystems Dynamics Research (BDR), Kobe, Japan. ichiro.hiratani@riken.jp.ORCID 0000-0003-3710-3540

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Faithful DNA replication is essential for genome integrity

Indexed as

DNA Replication TimingEmbryo, MammalianEmbryonic DevelopmentGenomic InstabilityAnimalsBlastocystCell DivisionChromosome AberrationsChromosome BreakpointsChromosome SegregationDNA DamageDNA-Directed DNA PolymeraseDNA RepairFemaleMaleMiceDNA-Directed DNA PolymeraseMultienzyme ComplexesNucleosidesReplisomes

Identifiers

PMID39198647
PMCPMC11410655

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.