Evidence map›Paper›PMID 39198645›Full record

ArticleNature2024

Fate induction in CD8 CAR T cells through asymmetric cell division.

Casey S Lee, Sisi Chen, Corbett T Berry, Andre R Kelly, Patrick J Herman, Sangwook Oh, Roddy S O'Connor, Aimee S Payne, Christoph T Ellebrecht

Abstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. CAR T cell persistence in cancer.Trends in cancer · 2025
    Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Casey S Lee *Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Sisi Chen *Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Corbett T BerryDepartment of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-9348-2034
Andre R KellyCenter for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Patrick J HermanDepartment of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Sangwook OhDepartment of Biomedical Science, Hallym University, Chuncheon, Republic of Korea.
Roddy S O'ConnorCenter for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Aimee S PayneDepartment of Dermatology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. asp2261@cumc.columbia.edu.ORCID 0000-0001-9389-7918
Christoph T EllebrechtDepartment of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. chell@pennmedicine.upenn.edu.ORCID 0000-0001-7656-0491

Funding

UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Robert H. Vonderheide · 1985 to 2026
$222.3M
Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Ronald G Collman · 1999 to 2026
$78.6M
Penn Dermatology Research Training ProgramT32AR007465 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Elizabeth Anne Grice, David Joel Margolis · 1986 to 2026
$9.0M
Study Design and Data AnalysisP30AR069589 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Elizabeth Anne Grice · 2016 to 2026
$8.6M
Directing the metabolic fate of CAR T cellsR01CA226983 · NCI · UNIVERSITY OF PENNSYLVANIA · PI JUNE, CARL H. · 2018 to 2022
$2.1M
Engineering disease-specific T cells for pemphigus therapyR01AR068288 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI PAYNE, AIMEE S · 2015 to 2019
$1.8M
Deciphering novel cell death mechanisms and metabolic reprogramming in response to microenvironmental stress.R35GM159930 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Christoph Thomas Ellebrecht · 2025 to 2026
$894k
Asymmetric cell division for fate commitment of human T cellsK08AR080266 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Christoph Thomas Ellebrecht · 2022 to 2026
$867k
NCI NIH HHS P30 CA016520NCI NIH HHS R01 CA226983NIAID NIH HHS P30 AI045008NIAMS NIH HHS K08 AR080266NIAMS NIH HHS P30 AR069589NIAMS NIH HHS R01 AR068288NIAMS NIH HHS T32 AR007465NIGMS NIH HHS R35 GM159930
6 · The paper itself

Abstract

Early expansion and long-term persistence predict efficacy of chimeric antigen receptor T cells (CARTs)

Indexed as

Asymmetric Cell DivisionCD8-Positive T-LymphocytesCell DifferentiationReceptors, Chimeric AntigenAnimalsCell LineageGlycolysisHumansIkaros Transcription FactorImmunologic MemoryImmunotherapy, AdoptiveMiceOxidation-ReductionProteomeRNA, MessengerTranscription FactorsIkaros Transcription FactorIKZF1 protein, humanProteomeReceptors, Chimeric AntigenRNA, MessengerTranscription Factors

Identifiers

PMID39198645
PMCPMC11410665

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.