ArticleNature2024
Fibrin drives thromboinflammation and neuropathology in COVID-19.
Abstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
85 citing papers in PubMed.
- Platelets mediate fibrin-induced thromboinflammation and NETosis through a GPVI-polyphosphate-FXIIa procoagulant axis.Blood vessels, thrombosis & hemostasis · 2026Article
- Why standard tests miss spike-induced clot alterations.Blood advances · 2026Article
- Plasmin-mediated fibrinolysis is required for hematopoietic recovery after 5-FU-induced myeloablation.Blood advances · 2026Article
- SARS-CoV-2 spike protein does not alter plasma fibrin clots.Blood advances · 2026Article
- Spike protein and fibrin(ogen) interactions.Blood advances · 2026Article
- Fibrinogen as a Molecular Bridge Linking SARS-CoV‑2 Immune Evasion and Endothelial Access?ACS pharmacology & translational science · 2026Article
- Closed-Loop Neuromodulation for Brain Fatigue: From Real-Time Biomarkers to Adaptive Intervention.International journal of molecular sciences · 2026Review
- Germinal Center Selection and Plasma Cell Differentiation.Immunological reviews · 2026Review
- Magnetoelastic Sensors-Based Pumpless Microfluidic Chip for Point-of-Care Coagulation Kinetics Monitoring.Biosensors · 2026Article
- CSF fibrinogen predicts longitudinal Tau accumulation in cognitively unimpaired older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Longitudinal analysis reveals myeloid cell contributions to murine neuroPASC pathogenesis.Nature communications · 2026Article
- Endothelial activation and thromboinflammation in Long COVID: revisiting the vascular axis in pediatric populations.Pediatric research · 2026Article
- Blood-Brain Barrier Changes and Related Microvascular Outcomes in Long-COVID: A Comprehensive Review.Life (Basel, Switzerland) · 2026Review
- CCL5 and CD11b-fibrin interactions regulate microglia migration and morphology in hyperinflammatory experimental cerebral malaria.Journal of neuroinflammation · 2026Article
- Article
- Neurological impairment in long COVID: implications for neurodegenerative disease.Journal of translational medicine · 2026Review
- Plasma proteomics improves thrombosis prediction in patients with cancer and identifies targetable IL-17-driven endothelial activation.Science translational medicine · 2026Article
- Beyond the barrier: Targeting blood-brain interactions for neuroprotection and repair.Neural regeneration research · 2026Article
- Transcutaneous Auricular Vagus Nerve Stimulation for Post-COVID-19 Condition: A Systematic Review and Critical Appraisal of Clinical Evidence.Journal of clinical medicine · 2026Review
- Therapeutic targeting of fibrin-microglia interactions ameliorates Alzheimer's disease-related hyperexcitability and brain network dysfunction.bioRxiv : the preprint server for biology · 2026Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
44 authors.
Jae Kyu Ryu *Center for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.ORCID 0000-0002-3992-4011
Zhaoqi Yan *Center for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.ORCID 0000-0001-9326-2920
Mauricio Montano *Gladstone Institute of Virology, San Francisco, CA, USA.ORCID 0000-0002-0353-0037
Elif G Sozmen *Center for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.
Karuna Dixit *Center for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.ORCID 0000-0003-3583-2512
Rahul K Suryawanshi *Gladstone Institute of Virology, San Francisco, CA, USA.ORCID 0000-0001-8374-669X
Yusuke MatsuiGladstone Institute of Virology, San Francisco, CA, USA.ORCID 0000-0002-6016-2867
Ekram HelmyGladstone Institute of Virology, San Francisco, CA, USA.
Prashant KaushalDepartment of Microbiology, Immunology and Molecular Genetics (MIMG), University of California Los Angeles, Los Angeles, CA, USA.
Sara K MakananiDepartment of Microbiology, Immunology and Molecular Genetics (MIMG), University of California Los Angeles, Los Angeles, CA, USA.
Thomas J DeerinckNational Center for Microscopy and Imaging Research, Center for Research on Biological Systems, University of California San Diego, La Jolla, CA, USA.
Anke Meyer-FrankeGladstone Institute of Neurological Disease, San Francisco, CA, USA.
Pamela E Rios CoronadoDepartment of Biology, Stanford University, Stanford, CA, USA.
Troy N TrevinoCenter for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.
Min-Gyoung ShinGladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.
Reshmi TognattaCenter for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.ORCID 0000-0001-7460-1843
Yixin LiuCenter for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.ORCID 0000-0003-1135-2805
Renaud SchuckCenter for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.
Lucas LeCenter for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.ORCID 0009-0005-7794-5736
Hisao MiyajimaCenter for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.
Andrew S MendiolaCenter for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.ORCID 0000-0002-2897-3299
Nikhita ArunCenter for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.
Brandon GuoCenter for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.
Taha Y TahaGladstone Institute of Virology, San Francisco, CA, USA.ORCID 0000-0002-7344-7490
Ayushi AgrawalGladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.ORCID 0000-0003-2940-8926
Eilidh MacDonaldCenter for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.
Oliver AriesCenter for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.
Aaron YanCenter for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.
Olivia WeaverCenter for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.
Mark A PetersenCenter for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.ORCID 0000-0003-1366-1353
Rosa Meza AcevedoCenter for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.
Maria Del Pilar S AlzamoraCenter for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.ORCID 0000-0001-8861-387X
Reuben ThomasGladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.
Michela TragliaGladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.
Valentina L KouznetsovaSan Diego Supercomputer Center, University of California San Diego, La Jolla, CA, USA.
Igor F TsigelnyCenter for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.
Alexander R PicoGladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.ORCID 0000-0001-5706-2163
Kristy Red-HorseDepartment of Biology, Stanford University, Stanford, CA, USA.ORCID 0000-0003-1541-601X
Mark H EllismanNational Center for Microscopy and Imaging Research, Center for Research on Biological Systems, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-8893-8455
Nevan J KroganGladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.
Mehdi BouhaddouDepartment of Microbiology, Immunology and Molecular Genetics (MIMG), University of California Los Angeles, Los Angeles, CA, USA.
Melanie OttGladstone Institute of Virology, San Francisco, CA, USA.ORCID 0000-0002-5697-1274
Warner C GreeneGladstone Institute of Virology, San Francisco, CA, USA. warner.greene@gladstone.ucsf.edu.ORCID 0000-0001-9896-8615
Katerina AkassoglouCenter for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA. katerina.akassoglou@gladstone.ucsf.edu.ORCID 0000-0002-2632-1465
Funding
RESEARCH PROJECT 2U19AI135990 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JEFFERY S COX · 2018 to 2026
$21.4MNeurovascular Interactions: Mechanisms, imaging, therapeutic potentialR35NS097976 · NINDS · J. DAVID GLADSTONE INSTITUTES · PI AKASSOGLOU, KATERINA · 2016 to 2023
$11.1MMOLECULAR AND CELLULAR IMMUNOLOGYT32AI007334 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 1988 to 2023
$11.0MMechanotransduction and transcriptional regulation during artery developmentR01HL128503 · NHLBI · STANFORD UNIVERSITY · PI Mary Red-Horse · 2015 to 2026
$5.8MNational Center for Microscopy and Imaging Research: A BRAIN Technology Integration and Dissemination ResourceU24NS120055 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELLISMAN, MARK H · 2021 to 2025
$5.4MTraining in Myocardial Biology at Stanford (TIMBS)T32HL094274 · NHLBI · STANFORD UNIVERSITY · PI Euan A Ashley, Daniel Bernstein · 2010 to 2026
$5.0MFibrinogen and vascular cognitive impairment: mechanisms, imaging, therapeuticsRF1AG064926 · NIA · J. DAVID GLADSTONE INSTITUTES · PI AKASSOGLOU, KATERINA, ELLISMAN, MARK H · 2019 to 2019
$4.5MThe National Center for Microscopy and Imaging Research, a Community-wide Scientific ResourceR24GM137200 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELLISMAN, MARK H · 2020 to 2022
$3.0MFEI TITAN HALO 300kV INTERMEDIATE VOLTAGE ELECTRON MICROSCOPES10OD021784 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELLISMAN, MARK H · 2017 to 2017
$1.9MAdvancing Multi-Color EM via Direct Detector-enabled 4D-STEMR01GM138780 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELLISMAN, MARK H · 2020 to 2023
$1.7MEpigenomic regulation of oxidative stress-producing innate immunity in neuroinflammationR00NS126707 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrew S Mendiola · 2024 to 2026
$706kBD FACSAria II Flow CytometerS10RR028962 · NCRR · J. DAVID GLADSTONE INSTITUTES · PI CAVROIS, MARIELLE · 2011 to 2011
$544kNCRR NIH HHS S10 RR028962NHLBI NIH HHS R01 HL128503NHLBI NIH HHS T32 HL094274NIAID NIH HHS K99 AI163868NIAID NIH HHS T32 AI007334NIAID NIH HHS U19 AI135990NIA NIH HHS RF1 AG064926NIGMS NIH HHS R01 GM138780NIGMS NIH HHS R24 GM137200NIH HHS S10 OD021784NINDS NIH HHS K99 NS126707NINDS NIH HHS R00 NS126707NINDS NIH HHS R35 NS097976NINDS NIH HHS U24 NS120055
Abstract
Life-threatening thrombotic events and neurological symptoms are prevalent in COVID-19 and are persistent in patients with long COVID experiencing post-acute sequelae of SARS-CoV-2 infection
Indexed as
BrainCOVID-19FibrinInflammationThrombosisAnimalsAntibodies, MonoclonalFemaleFibrinogenHumansImmunity, InnateKiller Cells, NaturalLungMacrophage ActivationMaleMental FatigueAntibodies, MonoclonalFibrinFibrinogenSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.