ArticleNature ecology & evolution2024
Plasmid-encoded insertion sequences promote rapid adaptation in clinical enterobacteria.
Article in Nature ecology & evolution, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- ISEmerging microbes & infections · 2026Article
- Loss of O-antigen due toScience advances · 2026Article
- The pQBR mercury resistance plasmids: a model set of sympatric environmental mobile genetic elements.Microbial genomics · 2026Article
- Translation Inhibiting Antibiotics Induce an asRNA Regulating Purine Metabolism inbioRxiv : the preprint server for biology · 2026Article
- Chemical inactivation of a bacterial immune system de-domesticates a temperate phage and promotes its spread.bioRxiv : the preprint server for biology · 2026Article
- Article
- Plasmids promote antimicrobial resistance through insertion sequence-mediated gene inactivation.Nature microbiology · 2026Article
- Phage-meropenem synergy against OXA-48-producing Klebsiella pneumoniae clinical isolates.npj antimicrobials and resistance · 2026Article
- Plasmid mutation rates scale with copy number.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Bile acid metabolism dysregulation following Helicobacter pylori eradication promotes plasmid-mediated antimicrobial resistance in the gut microbiome.The ISME journal · 2026Article
- Eco-evolutionary responses to plasmid-dependent phage constrain the spread of multidrug-resistance plasmids.The ISME journal · 2026Article
- Investigating the Trans Effects of IS<italic>1</italic> Transposases on Intragenomic DNA Movements in <italic>Escherichia coli</italic>.Microbial physiology · 2026Article
- Biofilm-associated proteins: from the gut biofilms to neurodegeneration.Gut microbes · 2025Review
- Metabolic remodeling of microorganisms by mobile genetic elements alters mutualistic community composition.mSystems · 2025Article
- The extended mobility of plasmids.Nucleic acids research · 2025Review
- Article
- Glucose alters the evolutionary response to gentamicin in uropathogenicMicrobiology (Reading, England) · 2025Article
- RNA-guided nucleases enable a gene drive of insertion sequences in plasmids.bioRxiv : the preprint server for biology · 2025Article
- Phenotypic and genetic heterogeneity ofMicrobial genomics · 2025Article
- An eco-evolutionary perspective on antimicrobial resistance in the context of One Health.iScience · 2025Review
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Abstract
Plasmids are extrachromosomal genetic elements commonly found in bacteria. They are known to fuel bacterial evolution through horizontal gene transfer, and recent analyses indicate that they can also promote intragenomic adaptations. However, the role of plasmids as catalysts of bacterial evolution beyond horizontal gene transfer is poorly explored. In this study, we investigated the impact of a widespread conjugative plasmid, pOXA-48, on the evolution of several multidrug-resistant clinical enterobacteria. Combining experimental and within-patient evolution analyses, we unveiled that plasmid pOXA-48 promotes bacterial evolution through the transposition of plasmid-encoded insertion sequence 1 (IS1) elements. Specifically, IS1-mediated gene inactivation expedites the adaptation rate of clinical strains in vitro and fosters within-patient adaptation in the gut microbiota. We deciphered the mechanism underlying the plasmid-mediated surge in IS1 transposition, revealing a negative feedback loop regulated by the genomic copy number of IS1. Given the overrepresentation of IS elements in bacterial plasmids, our findings suggest that plasmid-mediated IS1 transposition represents a crucial mechanism for swift bacterial adaptation.
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