ArticleNature communications2024
Uncovering the heritable components of multimorbidities and disease trajectories using a nationwide cohort.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Mapping the heritability of disease: a nationwide study.Nature communications · 2026Article
- The Cumulative Risk of Having a Family Member With a Diagnosed Mental Disorder: A Nationwide Study of Mental Disorders in Family Networks.Acta psychiatrica Scandinavica · 2026Article
- Article
- Mapping multimorbidity progression among 190 diseases.Communications medicine · 2024Article
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Authors and funding
17 authors.
Funding
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Abstract
Quantifying the contribution of genetics and environmental effects on disease initiation and progression, as well as the shared genetics of different diseases, is vital for the understanding of the disease etiology of multimorbidities. In this study, we leverage nationwide Danish registries to provide a granular atlas of the genetic origin of disease phenotypes for a cohort of all Danes 1978-2018 with partially known pedigree (n = 6.3 million). We estimate the heritability and genetic correlation between thousands of disease phenotypes using a novel approach that can be scaled to nationwide data. Our findings confirm the importance of genetics for a number of known associations and increase the resolution of heritability by adding numerous associations, some of which point to shared biologically origin of different phenotypes. We also establish the heritability of disease trajectories and the importance of sex-specific genetic contributions. Results can be accessed at https://h2.cpr.ku.dk/ .
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