Evidence map›Paper›PMID 39198456›Full record

ArticleScientific data2024

High-resolution segmentations of the hypothalamus and its subregions for training of segmentation models.

Livia Rodrigues, Martina Bocchetta, Oula Puonti, Douglas Greve, Ana Carolina Londe, Marcondes França, Simone Appenzeller, Leticia Rittner, Juan Eugenio Iglesias

Abstract readDataset
In one paragraph

Article in Scientific data, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Livia RodriguesMassachusetts General Hospital, Harvard Medical School, Boston Campus, USA. l180545@dac.unicamp.br.ORCID 0000-0002-3476-6640
Martina BocchettaDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK.
Oula PuontiMassachusetts General Hospital, Harvard Medical School, Boston Campus, USA.
Douglas GreveMassachusetts General Hospital, Harvard Medical School, Boston Campus, USA.
Ana Carolina LondeUniversidade Estadual de Campinas - School of Medical Sciences, São Paulo, Brazil.
Marcondes FrançaUniversidade Estadual de Campinas - School of Medical Sciences, São Paulo, Brazil.
Simone AppenzellerUniversidade Estadual de Campinas - School of Medical Sciences, São Paulo, Brazil.
Leticia Rittner *Universidade Estadual de Campinas, School of Electrical and Computer Engineering, São Paulo, Brazil.ORCID 0000-0001-8182-5554
Juan Eugenio Iglesias *Massachusetts General Hospital, Harvard Medical School, Boston Campus, USA.

Funding

FreeSurfer Development, Maintenance, and HardeningR01EB023281 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Bruce Fischl, Douglas Nowlin Greve · 2016 to 2026
$5.6M
Acquisition-independent machine learning for morphometric analysis of underrepresented aging populations with clinical and low-field brain MRIRF1AG080371 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Juan Eugenio Iglesias Gonzalez · 2023 to 2026
$4.0M
Diagnosing the undiagnosable: studies of Alzheimer disease mimics and confounders via "neuropathometry" of dissection photos with 3D scanningR01AG070988 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI IGLESIAS GONZALEZ, JUAN EUGENIO · 2021 to 2025
$2.7M
Open-source software for multi-scale mapping of the human brainRF1MH123195 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI FISCHL, BRUCE, IGLESIAS GONZALEZ, JUAN EUGENIO · 2020 to 2020
$2.0M
Alzheimer's Society AS-JF-19a-004-517Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brazilian Federal Agency for the Support and Evaluation of Graduate Education) 001Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brazilian Federal Agency for the Support and Evaluation of Graduate Education) 88887.716540/2022-00NIA NIH HHS R01 AG070988NIA NIH HHS RF1 AG080371NIBIB NIH HHS R01 EB023281NIMH NIH HHS RF1 MH123195
6 · The paper itself

Abstract

Segmentation of brain structures on magnetic resonance imaging (MRI) is a highly relevant neuroimaging topic, as it is a prerequisite for different analyses such as volumetry or shape analysis. Automated segmentation facilitates the study of brain structures in larger cohorts when compared with manual segmentation, which is time-consuming. However, the development of most automated methods relies on large and manually annotated datasets, which limits the generalizability of these methods. Recently, new techniques using synthetic images have emerged, reducing the need for manual annotation. Here we provide a dataset composed of label maps built from publicly available ultra-high resolution ex vivo MRI from 10 whole hemispheres, which can be used to develop segmentation methods using synthetic data. The label maps are obtained with a combination of manual labels for the hypothalamic regions and automated segmentations for the rest of the brain, and mirrored to simulate entire brains. We also provide the pre-processed ex vivo scans, as this dataset can support future projects to include other structures after these are manually segmented.

Indexed as

HypothalamusImage Processing, Computer-AssistedMagnetic Resonance ImagingHumansNeuroimaging

Identifiers

PMID39198456
PMCPMC11358401

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.