ArticleNature communications2024
Electrochemical meta-C-H sulfonylation of pyridines with nucleophilic sulfinates.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Radical enantioconvergent meta-C─H alkylation of pyridines.Science advances · 2026Article
- Emerging Strategies forJACS Au · 2026Review
- Photoinduced Palladium-Catalyzed Site-Selective Meta-Alkylation of Pyridines.Angewandte Chemie (International ed. in English) · 2026Article
- C3-H methylenephosphonylation of azaarenes enabled by catalyst-controlled regioselective cyclizative rearrangement.Chemical science · 2026Article
- A unified cobalt-electrocatalytic platform for enantio- and stereo-selective C-H and C-F functionalization ofChemical science · 2026Article
- Electrochemical functionalization of pyridines.Chemical science · 2026Review
- Room-temperature electrochemical hydroxyalkylation of pyridines.Nature communications · 2026Article
- Electrochemical Sulfonylation in Deep Eutectic Solvents Enables the Sustainable Synthesis of 2-Quinoline Sulfones.ChemSusChem · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Considering the indispensable significance and utilities of meta-substituted pyridines in medicinal, chemical as well as materials science, a direct meta-selective C-H functionalization of pyridines is of paramount importance, but such reactions remain limited and highly challenging. In general, established methods for meta C-H functionalization of pyridines rely on the utilization of tailored electrophilic reagents to realize the intrinsic polarity match. Herein, we report a complementary electrochemical methodology; diverse nucleophilic sulfinates allow meta-sulfonylation of pyridines through a redox-neutral dearomatization-rearomatization strategy by a tandem dearomative cycloaddition/hydrogen-evolution electrooxidative C-H sulfonation of the resulting oxazino-pyridines/acid-promoted rearomatization sequence. Besides, several salient features, including exclusive regiocontrol, remarkable substrate/functional group compatibility, scale-up potential, and facile late-stage modification, have been demonstrated, which further contributes to the practicality and adaptability of this approach.
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Registered trials
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