Evidence map›Paper›PMID 39198368›Full record

ArticleVirus genes2024

Comparative genomics and evolutionary analysis of dengue virus strains circulating in Pakistan.

Aziz Ul-Rahman, Muhammad Zubair Shabbir, Majeeda Rasheed, Nusrat Shafi, Kalsoom AbdulRazaq, Hamna Ramzan, Rauf Mehmood, Junaid Ali Khan

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Article in Virus genes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Aziz Ul-RahmanFaculty of Veterinary and Animal Sciences, MNS-University of Agriculture, Multan, Pakistan. drazizangel@gmail.com.
Muhammad Zubair ShabbirUniversity of Veterinary and Animal Sciences, Lahore, Pakistan.
Majeeda RasheedDepartment of Life Sciences, Khawaja Fareed University of Engineering and Information Technology (KFUEIT), Rahim Yar Khan, 64200, Pakistan.
Nusrat ShafiCh. Pervaiz Elahi Institute of Cardiology, Government of Pakistan, Multan, Pakistan.
Kalsoom AbdulRazaqFaculty of Veterinary and Animal Sciences, MNS-University of Agriculture, Multan, Pakistan.
Hamna RamzanFaculty of Veterinary and Animal Sciences, MNS-University of Agriculture, Multan, Pakistan.
Rauf MehmoodQuality Control Department, Assir Cooperative Company, Muhayil Assir, 61913, Kingdom of Saudi Arabia.
Junaid Ali KhanFaculty of Veterinary and Animal Sciences, MNS-University of Agriculture, Multan, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dengue fever virus (DENV) poses a significant public health risk in tropical and subtropical regions across the world. Although the dengue fever virus (DENV) exhibits significant genetic diversity and has the potential to evolve, there is a lack of comprehensive research on the comparative genomics and evolutionary dynamics of the virus in Pakistan. Phylogenetic analysis demonstrated the circulation of all four dengue virus serotypes (DENV-1, - 2, - 3, and - 4) with prevalent genotypes III and V within DENV-1, cosmopolitan genotype within DENV-2, genotype III within DENV-3, and genotype I within DENV-4 during 2006-2014. Based on the complete envelope region, genome-wide residue signature and genetic diversity indicate that there is a high level of genetic diversity among DENV-1 strains, while DENV-3 strains exhibit the least genetic diversity. Comparative analysis of all four DENV serotypes revealed that certain codons in DENV-2 and -4 were subject to strong purifying selection, while a few codon sites in the envelope region showed evidence of positive selection. These findings provided valuable insights into the comparative genomics and evolutionary pattern of DENV strains reported from Pakistan. Whether those characteristics conferred a fitness advantage to DENV-1 genotypes within a specific geography and time interval warrants further investigations. The findings of the current study will contribute to tracking disease dynamics, understanding virus transmission and evolution, and formulating effective disease control strategies.

Indexed as

DengueDengue VirusEvolution, MolecularGenetic VariationGenome, ViralGenomicsGenotypePhylogenyHumansPakistanSerogroupDengue virusEvolutionGenomic residuesPhylogenetic analysisSelection pressure analysis

Identifiers

PMID39198368

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.